Results 51 to 60 of about 9,178 (213)
Macrophage Targeting pH Responsive Polymersomes for Glucocorticoid Therapy
Pharmaceutics, 2019 Glucocorticoid (GC) drugs are the cornerstone therapy used in the treatment of inflammatory diseases. Here, we report pH responsive poly(2-methacryloyloxyethyl phosphorylcholine)−poly(2-(diisopropylamino)ethyl methacrylate) (PMPC−PDPA ...
Virgínia M. Gouveia +7 more
doaj +1 more source
Pharmaceutics, 2023 The development of new approaches for the treatment of the increasingly antibiotic-resistant pathogen Pseudomonas aeruginosa was targeted by enhancing the effect of local antimicrobial photodynamic therapy (aPDT) using poly(ethylene glycol)-block-poly ...
Kawaljit Kaur +3 more
doaj +1 more source
Electromechanical Limits of Polymersomes [PDF]
Physical Review Letters, 2001 Physical Review ...
Aranda-Espinoza, Helim +3 more
openaire +4 more sources
Bio‐Propelled Stomatocyte Nanomotors with Glutathione‐Responsiveness for Osteoarthritis Treatment
Angewandte Chemie, EarlyView.Glutathione (GSH)‐responsive stomatocyte nanomotors with encapsulated MTX utilize oxygen to achieve autonomous motion and undergo GSH‐induced dissociation, enhancing cellular uptake, tissue penetration, and MTX release within the osteoarthritis (OA) region, thereby improving therapeutic efficacy.
Jianhong Wang +12 more
wiley +2 more sources
Advanced Science, 2019 Understanding the diffusion of nanoparticles through permeable membranes in cell mimics paves the way for the construction of more sophisticated synthetic protocells with control over the exchange of nanoparticles or biomacromolecules between different ...
Hannes Gumz +7 more
doaj +1 more source
Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity [PDF]
, 2017 A new water-soluble photocatalyst for singlet oxygen generation is presented. Its absorption extends to the red part of the spectrum, showing activity up to irradiation at 660 nm.
Constable, Edwin C. +5 more
core +1 more source
Photoactivated Signaling Networks using DNA‐Based Synthetic Organelles as Biomimetic Protocells
Angewandte Chemie, EarlyView.Light‐triggered intercommunication between two types of organelle‐loaded liposomes lead to DNAzyme‐mediated on transcription‐guided structural reconfiguration of the organelles. ABSTRACT Membraneless organelles formed by phase‐separated nucleic acid or protein condensates play vital roles in regulating cellular functions.
Huiying Xue +6 more
wiley +2 more sources
Metabolically Active, Fully Hydrolysable Polymersomes [PDF]
Angewandte Chemie International Edition, 2019 AbstractThe synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile).
Zhu Y. +6 more
openaire +7 more sources
Targeting Neutrophilic Inflammation using Polymersome-Mediated Cellular Delivery [PDF]
, 2017 Neutrophils are key effector cells in inflammation and play an important role in neutralizing invading pathogens. During inflammation resolution, neutrophils undergo apoptosis before they are removed by macrophages, but if apoptosis is delayed ...
Avila-Olias, M. +4 more
core +2 more sources
Design of chimaeric polymersomes
Faraday Discussions, 2005 We discuss the development of hierarchical polymer particles, or variegated polymersome composites, in which at least two different components are phase separated within one polymersome chimaera. We briefly discuss the present status in experimental polymersome research, and then discuss a speculative design strategy, based on mesoscopic simulations ...
J. G. E. M. Fraaije +4 more
openaire +2 more sources