Results 121 to 130 of about 61,700 (266)

rDNAmine: A New Tool for the Analysis of Long Repetitive Sequences

open access: yesYeast, EarlyView.
This work introduces a novel approach for analysing long repetitive genomic sequences, combining a method to isolate large DNA molecules from individual chromosomes. We also describe the bioinformatics tool rDNAmine, which enables the isolation of long‐repeat sequences from reads obtained using the Oxford Nanopore method, as well as their preliminary ...
Agnieszka Czarnocka‐Cieciura   +1 more
wiley   +1 more source

Unusual backfolded binding poses of BAZ2A bromodomain binders

open access: yesActa Crystallographica Section D, EarlyView.
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove   +5 more
wiley   +1 more source

Long non-coding RNA maternally expressed gene 3 (<i>MEG3</i>) rs4081134 gene polymorphism and preeclampsia risk. [PDF]

open access: yesTurk J Obstet Gynecol
Saljoughi S   +6 more
europepmc   +1 more source

Recovery of male DNA acquired from carrion‐feeding insects in a simulated sexual assault scenario

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract When bodies of sexual assault victims are discovered in advanced stages of decomposition, the recovery of direct DNA evidence is often compromised, posing a challenge in criminal investigations. This study aimed to determine insect colonization and succession patterns on pig carcasses inoculated with semen and to assess the feasibility of ...
Tinotenda Angel Mupfumi   +2 more
wiley   +1 more source

The T Allele of the HNMT C314T Polymorphism Is Associated with a Reduced Risk of Idiopathic Parkinson's Disease in Mexican Patients. [PDF]

open access: yesBiomedicines
Bueno-Nava A   +10 more
europepmc   +1 more source

Genetic differentiation and adaptive evolution of buff‐tailed bumblebees in Asia

open access: yesInsect Science, EarlyView.
This study investigates the genetic differentiation and local adaptation of the buff‐tailed bumblebee (Bombus terrestris) across its European and Asian populations. Using whole‐genome resequencing, we identified distinct genetic differences between populations, with Asian B. terrestris representing a unique genetic resource.
Long Su   +14 more
wiley   +1 more source

Museomics Deciphers the Phylogeographic Differentiation and Conservation Status of a Montane Pheasant

open access: yesIntegrative Zoology, EarlyView.
Museum specimens provide a rich source of historical DNA, enabling insights into phylogenetic relationships and demographic history of the endangered Koklass Pheasant. Our findings uncovered a previously unrecognized population in Guizhou province and highlighted elevated extinction risk in populations from Anhui province and Southern China, informing ...
Zhiyong Jiang   +9 more
wiley   +1 more source

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