Results 51 to 60 of about 20,043 (225)
Multiple Fluorescence-Based PCR-SSCP Analysis Using Internal Fluorescent Labeling of PCR Products
BioTechniques, 1996 The method to internally label PCR products with multiple colored fluorescent dyes was developed and applied to multiple fluorescence-based PCR single-stranded conformational polymorphism (MF-PCRSSCP) analysis.
H. Iwahana +5 more
doaj +1 more source
Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques
Advanced Science, EarlyView.Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang +12 more
wiley +1 more source
Three novel mutations in the androgen receptor gene associated with partial androgen insensitivity syndrome: H570R, G589E and S759T [PDF]
Einstein (São Paulo), 2003 Three novel mutations in the androgen receptor gene were detectedby PCR-SSCP and characterized by DNA sequencing of genomicDNA samples from 3 unrelated patients with male pseudohermaphroditism caused by partial androgen insensitivity.
Patrícia Renovato Tobo +4 more
doaj
Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen +2 more
core +1 more source
Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance
Advanced Science, EarlyView.Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar +7 more
wiley +1 more source
Advanced Science, EarlyView.These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao +11 more
wiley +1 more source
Frontiers in Bioscience-LandmarkBacterial Artificial chromosome (BAC) recombineering is a powerful genetic manipulation tool for the efficient development of recombinant genetic resources.
Sun-Ku Chung
doaj +1 more source
G-quadruplexes in Prague: a Bohemian Rhapsody [PDF]
, 2018 The Sixth International Meeting on Quadruplex Nucleic Acids was held at the Hotel Internationale in Prague, Czech Republic from 31 May – 3 June 2017.
Mergny, Jean-Louis +2 more
core +3 more sources
Advanced Science, EarlyView.This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun +8 more
wiley +1 more source
Identification of the association between FABP4 gene polymorphisms and milk production traits in Sfakia sheep [PDF]
Archives Animal Breeding, 2019 The aim of this study was to estimate the effect of variation in the fatty acid binding protein 4 gene (FABP4) on milk production traits in Greek Sfakia sheep.
A. H. M. Ibrahim +4 more
doaj +1 more source