Results 91 to 100 of about 62,432 (254)

Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]

, 2017
Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio, Bondã¬, Roslen, Imperi, Francesco, Leoni, Livia, Longo, Francesca, Messina, Marco, Pillai, Cejoice Ramachandran, Rampioni, Giordano, Visca, Paolo   +8 more
core   +2 more sources

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023

Communications Medicine
Background Development of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a severe challenge to public health. Here we aimed to perform a retrospective study of prevalence and molecular characteristics of polymyxin ...
Miaomiao Xie, Yanyan Zhang, Kaichao Chen, Ning Dong, Hongwei Zhou, Yonglu Huang, Congcong Liu, Edward Wai-Chi Chan, Sheng Chen, Rong Zhang   +9 more
doaj   +1 more source

\u3cem\u3eRhizobium etli\u3c/em\u3e CE3 Bacteroid Lipopolysaccharides Are Structurally Similar but Not Identical to Those Produced by Cultured CE3 Bacteria [PDF]

, 2007
Rhizobium etli CE3 bacteroids were isolated from Phaseolus vulgaris root nodules. The lipopolysaccharide (LPS) from the bacteroids was purified and compared with the LPS from laboratory-cultured R.
Carlson, Russell W., D\u27Haeze, Wim, Freshour, Glenn, Leoff, Christine, Noel, K. Dale   +4 more
core   +1 more source

An engineered epididymal cell line provides a sustainable source of functional extracellular vesicles for in vitro sperm preservation: A multi‐omics and functional study

VIEW, EarlyView.
ABSTRACT This study investigated the function of epididymal extracellular vesicles (EVs) in overcoming sperm post‐testicular modification deficiencies. Although EVs derived from the epididymis play a crucial role in intercellular communication and molecular exchange, there is limited research addressing how EVs released by in vitro cultured epididymal ...
Long Li, Haonan Zhao, Yibo Li, Qixin Xu, Yang Zi, Tingting Chu, Heran Cao, Shujuan Liu, Zifang Wu, Huanqiang Zhao, Wuzi Dong   +10 more
wiley   +1 more source

Nephrotoxicity and Efficacy Assessment of Polymyxin Use in 92 Transplant Patients [PDF]

, 2013
Polymyxins are old antimicrobials, discontinued for many years because of nephrotoxicity and neurotoxicity reports and reintroduced recently due to the increasing frequency of multiresistant Gram-negative bacterial infections.
Camargo, Luis Fernando A., Marra, Alexandre R., Mostardeiro, Marcelo M., Pereira, Carlos A. P., Pestana, Jose O. M.   +4 more
core   +1 more source

Cell membrane‐coated nanoparticles for dermatological diseases

VIEW, EarlyView.
Skin disorders are challenging to treat due to complex barrier functions and limited conventional therapies. Biomimetic cell membrane‐coated nanoparticles (CM‐NPs) offer a superior nanomedicine approach by evading immune detection and enabling precise targeting.
Shuaijun Zou, Baojie Zhang, Yuanjie Zhu
wiley   +1 more source

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum [PDF]

, 2017
In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm susceptibility on biotic surfaces, using a
Coenye, Tom, Crabbé, Aurélie, Davis, Richard, De La Fuente-Nùñez, César, Hancock, Robert EW, Ledesma, Maria A, Liu, Yulong, Matthijs, Nele, Nickerson, Cheryl A., Rigole, Petra, Sarker, Shameema, Van Houdt, Rob   +11 more
core   +1 more source

Twin‐compartment solid–liquid cells for neutron reflectometry

Journal of Applied Crystallography, EarlyView.
We introduce a twin‐compartment solid–liquid cell for neutron reflectometry that divides a single substrate into two independent measurement areas, doubling sample capacity and enabling direct side‐by‐side comparisons. This sample environment also reduces alignment and sample preparation time and has been successfully tested on both vertical and ...
Nicoló Paracini, Hannah Burrall, Thomas Saerbeck, Philipp Gutfreund, Giovanna Fragneto, Luke A. Clifton, Thomas Arnold, Marité Cárdenas   +7 more
wiley   +1 more source

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Allergy, EarlyView.
Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T‐cell release of barrier‐repressing cytokines (IL‐4, IL‐13, IL‐22, OSM). Cytokine signalling drives JAK‐dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic‐mediated eradication of S. aureus induces
Maria Gluud, Emil M. Pallesen, Ziao Zeng, Martin R. J. Namini, Chella Krishna Vadivel, Lise Mette Rahbek Gjerdrum, Lang Yan, Sana Ahmad, Lise M. Lindahl, Michael Bzorek, Maria R. Kamstrup, Saptaswa Dey, Sisse Rye Ostrowski, Erik Sørensen, Pia Rantakari, Charlotte Menne Bonefeld, Carsten Geisler, Anders Woetmann, Riitta Lahesmaa, Lars Iversen, Peter Wolf, Thomas Litman, Terkild B. Buus, Niels Ødum   +23 more
wiley   +1 more source