Results 1 to 10 of about 58,749 (205)

Bordetella parapertussis Survives inside Human Macrophages in Lipid Raft-Enriched Phagosomes [PDF]

, 2014
Bordetella parapertussis is a human pathogen that causes whooping cough. The increasing incidence of B. parapertussis has been attributed to the lack of cross protection induced by pertussis vaccines. It was previously shown that B. parapertussis is able
Gorgojo, Juan Pablo, Harvill, Eric, Rodriguez, Maria Eugenia   +2 more
core   +3 more sources

Polymyxin B and fusidic acid, a novel potent synergistic combination against Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance

Frontiers in Microbiology, 2023
The increasing prevalence of multidrug-resistant (MDR) Gram-negative bacteria and comparatively limited options of antibiotics pose a major threat to public health worldwide.
Shuying Chen, Peiyao Zhou, Chunyang Wu, Jie Wang, Ying Zhou, Jiao Zhang, Bingjie Wang, Huilin Zhao, Lulin Rao, Meilan Li, Fangyou Yu, Fangyou Yu, Chunchan Lin   +12 more
doaj   +1 more source

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source

A Review of the Clinical Pharmacokinetics of Polymyxin B

Antibiotics, 2019
Polymyxin B remains an antibiotic of last resort because of its toxicities. Although newer therapies are becoming available, it is anticipated that resistance to these agents will continue to emerge, and understanding the safest and most efficacious ...
Sean N. Avedissian, Jiajun Liu, Nathaniel J. Rhodes, Andrew Lee, Gwendolyn M. Pais, Alan R. Hauser, Marc H. Scheetz   +6 more
doaj   +1 more source

Fosmidomycin Decreases Membrane Hopanoids and Potentiates the Effects of Colistin on Burkholderia multivorans Clinical Isolates [PDF]

, 2014
Burkholderia cepacia complex (Bcc) pulmonary infections in people living with cystic fibrosis (CF) are difficult to treat because of the extreme intrinsic resistance of most isolates to a broad range of antimicrobials.
Dalleska, Nathan F., Hird, Trevor J., Lee, Tracy D., Malott, Rebecca J., Newman, Dianne K., Speert, David P., Wu, Chia-Hung, Zlosnik, James E. A.   +7 more
core   +1 more source

Cation Concentration Variability of Four Distinct Mueller-Hinton Agar Brands Influences Polymyxin B Susceptibility Results [PDF]

, 2012
Polymyxins have been the only alternative therapeutic option for the treatment of serious infections caused by multidrug-resistant Acinetobacter baumannii or Pseudomonas aeruginosa isolates.
Bispo, Paulo J. M., Gales, Ana C., Girardello, Raquel, Yamanaka, Tiago M.   +3 more
core   +2 more sources

Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells

Antibiotics, 2022
Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in ...
Mengyao Li, Mohammad A. K. Azad, Maizbha U. Ahmed, Yan Zhu, Jiangning Song, Fanfan Zhou, Hak-Kim Chan, Tony Velkov, Qi Tony Zhou, Jian Li   +9 more
doaj   +1 more source

Polymyxin B vs colistin: The comparison of neurotoxic and nephrotoxic effects of the two polymyxins

Journal of Global Antimicrobial Resistance
AIM: To compare polymyxin B with colistimethate sodium (CMS) regarding neurotoxicity, nephrotoxicity, and 30-day mortality in patients with multi-drug resistant (MDR) gram-negative.
Pınar Aysert Yıldız, Ozge Ozgen Top, Ahmet Furkan Senturk, Sait Kanık, H. Selcuk Ozger, Murat Dizbay   +5 more
doaj   +2 more sources

Predictors of polymyxin B treatment failure in Gram-negative healthcare-associated infections among critically ill patients

Journal of Microbiology, Immunology and Infection, 2018
Background: With increasing prevalence and spread of multidrug resistant Gram-negative infections, parenteral polymyxins resurged in clinical practice.
Bahiah Ismail, Mohd Nazri Shafei, Azian Harun, Saedah Ali, Mahamarowi Omar, Zakuan Zainy Deris   +5 more
doaj   +1 more source

Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria

BMC Microbiology, 2022
Background The heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure.
Jun Li, Mengli Tang, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Mingxiang Zou   +6 more
doaj   +1 more source