Results 31 to 40 of about 58,749 (205)

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]

, 2016
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe, Forgione, Mariantonietta, Forneris, Federico, Lucidi, Alessia, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Mehdipour, Parinaz, Pilotto, Simona, Rotili, Dante, Speranzini, Valentina, Velankar, Sameer   +11 more
core   +2 more sources

Metabolomic profiling of polymyxin-B in combination with meropenem and sulbactam against multi-drug resistant Acinetobacter baumannii

Frontiers in Microbiology, 2022
Empirical therapies using polymyxins combined with other antibiotics are recommended in the treatment of Acinetobacter baumannii infections. In the present study, the synergistic activities of polymyxin-B, meropenem, and sulbactam as combination therapy ...
Shixing Zhu, Jiayuan Zhang, Chu Song, Yuwei Liu, Charles Oo, M. Tobias Heinrichs, Zhihua Lv, Zhihua Lv, Yuanqi Zhu, Sherwin K. B. Sy, Pan Deng, Mingming Yu, Mingming Yu   +12 more
doaj   +1 more source

In Vitro and In Vivo Synergism of Fosfomycin in Combination with Meropenem or Polymyxin B against KPC-2-Producing Klebsiella pneumoniae Clinical Isolates

Antibiotics, 2023
Fosfomycin disodium is a potential therapeutic option to manage difficult-to-treat infections, especially when combined with other antimicrobials. In this study, we evaluated the activity of fosfomycin in combination with meropenem or polymyxin B against
Aghata Cardoso da Silva Ribeiro, Yohanna Carvalho dos Santos Aoun Chikhani, Tiago Barcelos Valiatti, André Valêncio, Mariana Neri Lucas Kurihara, Fernanda Fernandes Santos, Luciene Andrade da Rocha Minarini, Ana Cristina Gales   +7 more
doaj   +1 more source

ZraP is a periplasmic molecular chaperone and a repressor of the zinc-responsive two-component regulator ZraSR [PDF]

, 2011
The bacterial envelope is the interface with the surrounding environment and is consequently subjected to a barrage of noxious agents including a range of compounds with antimicrobial activity.
Andrea Hall, Appia-Ayme, Bader, Buelow, Cherepanov, Corinne Appia-Ayme, Danese, Datsenko, Delaney, Demeler, DiGiuseppe, Elaine Patrick, Fardini, Fleischer, Gary Rowley, Gemski, Graham, Graham, Hagenmaier, Hoiseth, Houry, Huang, Isaac, Kwon, Leonhartsberger, Merdanovic, Noll, Quan, Raffa, Raivio, Raivio, Rowley, Shiny Rajadurai, Tedin, Thede, Thomas A. Clarke, Uzzau, Zhao, Zhou   +38 more
core   +1 more source

Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis

Brazilian Journal of Infectious Diseases, 2018
A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients.
Cely Saad Abboud, Gauri G. Rao, Ercilia E. Souza, Alexandre P. Zavascki, Carlos Kiffer   +4 more
doaj   +1 more source

Global burden of colistin-resistant bacteria : mobilized colistin resistance genes study (1980-2018) [PDF]

, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat.
Elbediwi, Mohammed, Fang, Weihuan, Feng, Youjun, Li, Xiaoliang, Li, Yan, Pan, Hang, Paudyal, Narayan, Rajkovic, Andreja, Rankin, Shelley C., Xie, Shaohua, Yue, Min   +10 more
core   +1 more source

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]

, 2012
BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M, Hellman, Judith, Mesa, Kailin R, Prakash, Arun, Wilhelmsen, Kevin, Xu, Fengyun   +5 more
core   +1 more source

POLYMYXIN B AND HEART MUSCLE

British Journal of Anaesthesia, 1979
The effects of the polypeptide antibiotic, polymyxin B, on myocardial contractility were studied in t;e isolated rat heart muscle. Five different doses of polymyxin B were tested. There were no changes in contractility with does ranging from the clinical therapeutic value to three times greater.
Y Z, Sohn, R L, Katz
openaire   +2 more sources

Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro [PDF]

, 2012
Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura, Parnham, Michael J.   +6 more
core   +1 more source

Risk factors for polymyxin B-associated acute kidney injury

International Journal of Infectious Diseases, 2022
Objectives: This study aimed to assess the current incidence and risk factors for polymyxin B-associated acute kidney injury (AKI) in Chinese hospitals for a more effective clinical use for polymyxin B.
Kang Chang, Haibo Wang, Jianping Zhao, Xianghong Yang, Bo Wu, Wenkui Sun, Man Huang, Zhenshun Cheng, Hong Chen, Yuanlin Song, Ping Chen, Xiangqi Chen, Xin Gan, Wanli Ma, Lihua Xing, Yimin Wang, Bin Cao   +16 more
doaj   +1 more source