Results 41 to 50 of about 58,749 (205)

Polymyxin b therapy for multidrug resistant gram negative infections : outcome and risk factors for treatment failure in critical care [PDF]

, 2015
Objective: Polymyxins have re-administered in clinical practice due to the dry antibiotic development pipeline and worldwide increasing infections caused by multi-drug resistant (MDR) gram negative bacteria.
Ismail, Bahiah
core  

Tn5AraOut mutagenesis for the identification of Yersinia pestis genes involved in resistance towards cationic antimicrobial peptides [PDF]

, 2011
Bacterial pathogens display a variety of protection mechanisms against the inhibitory and lethal effects of host cationic antimicrobial peptides (CAMPs).
Galvan, Estela Maria, Guo, Jitao, Liu, Shu Lin, Nair, Manoj K. M., Schifferli, Dieter M.   +4 more
core   +2 more sources

Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications [PDF]

, 2016
This article reports the conclusions of the second part of a consensus expert conference on the nomenclature of renal replacement therapy (RRT) techniques currently utilized to manage acute kidney injury and other organ dysfunction syndromes in ...
Bagshaw, S. M., Balducci, A., Baldwin, I., Barbarigo, F., Bellomo, R., Bellomo, Rinaldo, Braganã³, P., Braunsky, J., Calletti, F., Cerda, J., Cerda, Jorge, Chawla, L., De Gaudio, A. Raffaele, De Rosa, S., De Rosa, Silvia, Di Somma, S., Doi, K., Dosil Rosende, P., Emmett, M., Fecondini, L., Galavotti, D., Garzotto, F., Garzotto, Francesco, Gibney, N., Goldstein, S. L., Guadagni, G., Honore, Patrick M., Honorã, P., Hoste, E., Inadome, S., Kashani, K., Katz, N., Kellum, J., Kenley, R., Kobayashi, Y., Lannoy, J., Lewington, A., Lorenzin, Anna, Mariano, F., Mccullough, P. A., Mehta, R. L., Menneguerre, J., Mettifogo, M., Neri, M., Neri, Mauro, Ostermann, M., Pani, A., Payen, Didier, Pirazzoli, P., Pohlmeier, R., Pouchoulin, D., Ricci, Z., Ricci, Zaccaria, Ronco, C., Ronco, Claudio, Rosner, M., Samoni, Sara, Seamann, M., Shaw, A., Tolwani, A., Villa, G., Villa, Gianluca, Vincent, J. L., Vincent, Jean-Louis, Wendon, J., Wendon, Julia, Zaccaria, Marta   +66 more
core   +4 more sources

Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis

Microbiology Spectrum, 2022
Polymyxin B is a last-line antibiotic for extensively resistant Gram-negative bacterial infection. Skin hyperpigmentation is a serious side effect induced by polymyxin B that severely compromises the psychological health and compliance of patients.
Chuhan Zhang, Xiaofen Liu, Hailan Wu, Yu Wang, Yaxin Fan, Beining Guo, Xingchen Bian, Xin Li, Jing Zhang   +8 more
doaj   +1 more source

The susceptibility of pathogenic free-living amebae to chemotherapeutic agents : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University [PDF]

, 1979
The treatment of infections caused by pathogenic free-living amebae (PFLA) has, until only recently, been far from successful. The continued screening of chemotherapeutic agents against amebae of the genera Naegleria and Acanthamoeba is therefore of the ...
Donald, Jennifer Jane
core  

Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care : systematic review and network meta-analysis [PDF]

, 2014
Peer reviewedPublisher ...
Glen, John, MacLennan, Graeme, Price, Richard, SuDDICU Collaboration   +3 more
core   +1 more source

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

Frontiers in Pharmacology, 2018
Polymyxins are currently used as the last-resort antibiotics against multidrug-resistant Acinetobacter baumannii. As resistance to polymyxins emerges in A. baumannii with monotherapy, combination therapy is often the only remaining treatment option.
Thien B. Tran, Thien B. Tran, Phillip J. Bergen, Darren J. Creek, Tony Velkov, Tony Velkov, Jian Li   +6 more
doaj   +1 more source

Polymyxin B-induced rhabdomyolysis

Medicine, 2020
Abstract Rationale: Polymyxin B has been used to treat extensively drug-resistant gram-negative bacteria and shown a better antibacterial effect in the clinic at present. Meanwhile, polymyxin B is associated with several adverse effects.
Ming Ni, Xiangdong Meng, Limin Wang, Yanan Zhao, Min Yu, Sheng Shi   +5 more
openaire   +2 more sources

Bacterial Mixology: Combining Pharmacodynamic Models to Predict In Vitro Competition of MCR-1-Harboring E. coli

Antibiotics, 2021
The emergence of mobile colistin resistance (mcr)-mediated polymyxin resistance has resulted in a significant detriment to the utility of the polymyxins in the clinical setting.
Nicholas M. Smith, Arthur Chan, Thomas D. Nguyen, Jacob T. Dumbleton   +3 more
doaj   +1 more source

Tobramycin Reduces Pulmonary Toxicity of Polymyxin B via Inhibiting the Megalin-Mediated Drug Uptake in the Human Lung Epithelial Cells

Pharmaceutics
Accumulation of polymyxins in the lung epithelial cells can lead to increased mitochondrial oxidative stress and pulmonary toxicity. Aminoglycosides and polymyxins are used, via intravenous and pulmonary delivery, against multidrug-resistant Gram ...
Maizbha Uddin Ahmed, Jian Li, Qi (Tony) Zhou   +2 more
doaj   +1 more source