Results 51 to 60 of about 58,749 (205)
Annals of Clinical Microbiology and Antimicrobials, 2018 Background The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations.
Ritesh Aggarwal, Arun Dewan
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Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation [PDF]
, 2014 Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little ...
Bengoechea, J +14 more
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Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus [PDF]
, 1994 Endotoxin (lipopolysaccharide, LPS) is commonly found as a contaminant in plasmid DNA preparations. We demonstrate here that the quantities of LPS typically contaminating DNA preparations can generate a toxicity to primary cells (primary human skin ...
Baker, A. +4 more
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Escenario actual de la resistencia a la colistina mediada por plásmidos en América Latina [PDF]
, 2019 Colistin resistance can occur by chromosomal mutations and by acquisition of plasmid-carrying determinants, mainly mcr-1. In the recent years, we have observed the outburst of this resistance gene in our region. Due to the risk of the rapid dissemination
Di Conza, José Alejandro +2 more
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Polymyxin B-induced skin and nail hyperpigmentation in an adult
Pigment International, 2023 Polymyxin B is a reserve drug for resistant gram-negative bacterial infections. A rare side effect of polymyxin B is cutaneous hyperpigmentation, which characteristically involves face and neck. This is commonly reported in pediatric population.
Mahendra M Kura, Poornima D Sonawane
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Structural insights into Escherichia coli polymyxin B resistance protein D with X-ray crystallography and small-angle X-ray scattering [PDF]
, 2014 BACKGROUND: Polymyxin B resistance protein D (PmrD) plays a key role in the polymyxin B-resistance pathway, as it is the signaling protein that can act as a specific connecter between PmrA/PmrB and PhoP/PhoQ.
Changill Ban +3 more
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Frontiers in Pharmacology, 2022 The latest PK/PD findings have demonstrated negligible efficacy of intravenous polymyxins against pulmonary infections. We investigated pharmacokinetic/pharmacodynamic (PK/PD)-based breakpoints of polymyxin B for bloodstream infections and the ...
Xingchen Bian +19 more
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Peptides as potent antimicrobials tethered to a solid surface: Implications for medical devices [PDF]
, 2008 Medical devices are an integral part of therapeutic management; despite their importance, they carry a significant risk of microbial infection. Bacterial attachment to a medical device is established by a single, multiplying organism, leading to ...
Ahmed El-Ghannam +8 more
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BMC Microbiology, 2019 Background Although the most widely accepted mechanism of action for polymyxins is related to bacterial lysis via disruption, we hypothesized that this antimicrobial drug class could have other effects on Pseudomonas aeruginosa planktonic and sessile ...
Marlucy Rodrigues Lima +10 more
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Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity [PDF]
, 2014 The ExPortal protein secretion organelle in Streptococcus pyogenes is an anionic phospholipid-containing membrane microdomain enriched in Sec translocons and postsecretion protein biogenesis factors.
Caparon, Michael G. +3 more
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