Results 71 to 80 of about 58,749 (205)

Risk Factors and Molecular Mechanism of Polymyxin B Resistance in Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Fujian, China

Infection and Drug Resistance, 2022
Xiaohong Xu,1,* Rongping Zhu,1,* Siyan Lian,1 Hui Zhang,2 Xin Chen,2 Lingfang Fan,1 Peisong Chen,2 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 2Medical ...
Xu X, Zhu R, Lian S, Zhang H, Chen X, Fan L, Chen P, Cao Y   +7 more
doaj  

Washout policies in long-term indwelling urinary catheterisation in adults [PDF]

, 2017
Background  People requiring long-term bladder draining with an indwelling catheter can experience catheter blockage. Regimens involving different solutions can be used to wash out catheters with the aim of preventing blockage.
Airaksinen, Andersson, Atkins, Bach, Bibby, Bruun, Capewell, Davies, Elliott, Elliott, Evans, Garibaldi, Gelman, Getliffe, Getliffe, Getliffe, Getliffe, Getliffe, Gould, Hagen, Hamory, Hesse, Hesse, Kennedy, Kennedy, King, Kohler-Ockmore, Kunin, Linsenmeyer, McNicoll, Meyers, Moore, Muncie, Padawer, Pellowe, Pomfret, Robertson, Roe, Ruwaldt, Saint, Sinclair, Stark, Stickler, Sørbye, Vainrub, Waites, Ware, Warren, Wilks, Zigmond   +49 more
core   +5 more sources

Emergence of Polymyxin Resistance Driven by a PhoQ Mutation in KPC-2-Producing Klebsiella pneumoniae

Antibiotics
Background: The emergence of polymyxin-resistant, carbapenem-resistant Klebsiella pneumoniae (CRKP) presents a critical challenge to clinical management.
Huijuan Song, Cui Jian, Lu Gong, Ziyong Sun, Zhongju Chen, Yue Wang   +5 more
doaj   +1 more source

Synergistic effect of silver nanoparticles and polymyxin B against biofilm produced by Pseudomonas aeruginosa isolates of pus samples in vitro

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Pseudomonas aeruginosa (P. aeruginosa) is an aerobic gram-negative, non-spore forming, rod-shaped bacterium. It accelerates the decline in lung function and ultimately leads to increased mortality and morbidity rate.
Muhammad Salman, Rizwana Rizwana, Hayat Khan, Iqbal Munir, Muhammad Hamayun, Aquib Iqbal, Abdul Rehman, Khalid Amin, Ghayour Ahmed, Majid Khan, Ajmal Khan, Faiz Ul Amin   +11 more
doaj   +1 more source

An Update on the arsenal for multidrug-resistant Acinetobacter infections: Polymyxin antibiotics

International Journal of Infectious Diseases, 2015
Objective: To review recent clinical pharmacokinetic and pharmacodynamic data to optimize dosing regimens for polymyxin B and colistin for treatment of infections due to A. baumannii.
Zahra Kassamali, Rupali Jain, Larry H. Danziger   +2 more
doaj   +1 more source

Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]

, 2018
Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon, De Waele, Stijn, Deforce, Dieter, Depluverez, Sofie, Devreese, Bart, Planckaert, Sören, Schoovaerts, Jolien   +6 more
core   +2 more sources

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Computational and Structural Biotechnology Journal, 2018
Polymyxins are amongst the most important antibiotics in modern medicine, in recent times their clinical utility has been overshadowed by nosocomial outbreaks of polymyxin resistant MDR Gram-negative ‘superbugs’.
Maytham Hussein, Mei-Ling Han, Yan Zhu, Elena K. Schneider-Futschik, Xiaohan Hu, Qi Tony Zhou, Yu-Wei Lin, Dovile Anderson, Darren J. Creek, Daniel Hoyer, Jian Li, Tony Velkov   +11 more
doaj   +1 more source

Performance of Population Pharmacokinetic Models in Predicting Polymyxin B Exposures

Microorganisms, 2020
Polymyxin B is the last line of defense in treating multidrug-resistant gram-negative bacterial infections. Dosing of polymyxin B is currently based on total body weight, and a substantial intersubject variability has been reported.
Vincent H. Tam, Lawrence S. Lee, Tat-Ming Ng, Tze-Peng Lim, Benjamin P. Z. Cherng, Hafeez Adewusi, Kim H. Hee, Ying Ding, Shimin Jasmine Chung, Li-Min Ling, Piotr Chlebicki, Andrea L. H. Kwa, David C. Lye   +12 more
doaj   +1 more source

Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system [PDF]

, 2011
We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011) and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial Genome annotation of Era7 Bioinformatics, predicts ORFs and annotates them based on ...
Eduardo Pareja, Eduardo Pareja-Tobes, Marina Manrique, Pablo Pareja-Tobes, Raquel Tobes   +4 more
core   +2 more sources

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Clapp, BR, Deanfield, JE, Gallimore, JR, Hineorani, AD, Hirschfield, GM, MacAllister, RJ, Pepys, MB, Singer, M, Stidwill, RP, Storry, C, Vallance, P   +10 more
core   +1 more source