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Clinical Microbiology Reviews, 2008 SUMMARY The global emergence of multidrug-resistant gram-negative bacilli has spurred a renewed interest in polymyxins. Once discarded due to concerns regarding nephrotoxicity and neurotoxicity, polymyxins now hold an important role in the antibiotic armamentarium.
David, Landman +3 more
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Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane [PDF]
Communications BiologyPolymyxins are often administered as last resort antibiotics for Gram-negative bacterial infections. However, given unwanted side-effects, efficacy and recent reports of resistance against polymyxins, there is an urgency to develop alternatives.
Dheeraj Prakaash, Syma Khalid
doaj +2 more sources
Development of polymyxin- and aminoglycoside-based outer membrane permeabilizers: a review [PDF]
Frontiers in MicrobiologyThe prevalence of antimicrobial resistance (AMR) necessitates the development of alternative therapeutic options, particularly against critical priority Gram-negative pathogens.
Danzel Marie Ramirez +2 more
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Antibiotics, 2022 Polymyxins are considered a last-line treatment against infections caused by multidrug-resistant (MDR) Gram-negative bacteria. In addition to their use as a potent antibiotic, polymyxins have also been utilized as outer membrane (OM) permeabilizers ...
Danzel Marie Ramirez +4 more
exaly +3 more sources
Polypeptide Self-Assembled Nanoparticles as Delivery Systems for Polymyxins B and E
Pharmaceutics, 2020 Polymyxins are peptide antibiotics that are highly efficient against many multidrug resistant pathogens. However, the poor stability of polymyxins in the bloodstream requires the administration of high drug doses that, in turn, can lead to polymyxin ...
Natalia Zashikhina +2 more
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Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance
Membranes, 2020 Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to their potential clinical toxicity, especially nephrotoxicity.
Carole Ayoub Moubareck
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PLoS ONE, 2014 BackgroundMulti-drug resistance among Acinetobacter baumannii increases the need for polymyxins. We conducted a meta-analysis aimed to assess the efficacy and safety of polymyxins for the treatment of Acinetobacter baumannii infection.MethodsWe searched ...
Chuanmin Tao
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Polymyxins: recent advances and challenges
Frontiers in PharmacologyAntibiotic resistance is a pressing global health challenge, and polymyxins have emerged as the last line of defense against multidrug-resistant Gram-negative (MDR-GRN) bacterial infections.
Shan Yang +4 more
exaly +3 more sources
Next-Generation Polymyxin Class of Antibiotics: A Ray of Hope Illuminating a Dark Road
Antibiotics, 2022 Although new-generation antimicrobials, in particular β-lactam/β-lactamase inhibitors, have largely replaced polymyxins in carbapenem-resistant Gram-negative bacterial infections, polymyxins are still needed for carbapanem-resistant Acinetobacter ...
Abdullah Tarık Aslan +2 more
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Giant, 2023 Polymyxins are credited as the last line of defense against the clinical multi-resistant Gram-negative pathogen infections. However, their clinical use is limited by high nephrotoxicity and neurotoxicity, and less effectiveness against mature biofilms ...
Yongxin Yang +6 more
doaj +1 more source