Results 91 to 100 of about 15,147 (259)

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin [PDF]

, 2017
Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.ijantimicag.2017.02.012.Antimicrobial combinations involving antimicrobial peptides (AMPs) attract considerable attention within current antimicrobial ...
Jorge, Paula, Lourenço, Anália, Pereira, Maria Olívia, Pérez-Pérez, Martín, Rodríguez, Gael Pérez   +4 more
core   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Potent activity of polymyxin B is associated with long-lived super-stoichiometric accumulation mediated by weak-affinity binding to lipid A

Nature Communications
Polymyxins are gram-negative antibiotics that target lipid A, the conserved membrane anchor of lipopolysaccharide in the outer membrane. Despite their clinical importance, the molecular mechanisms underpinning polymyxin activity remain unresolved.
Kerry R. Buchholz, Mike Reichelt, Matthew C. Johnson, Sarah J. Robinson, Peter A. Smith, Steven T. Rutherford, John G. Quinn   +6 more
doaj   +1 more source

IMPACT OF ANTIMICROBIAL USE ON RESISTANCE IN GRAM-NEGATIVE BACILLI: A SECONDARY ANALYSIS OF ANVISA DATA (2019–2023) IN HOSPITALIZED ADULTS IN ICUS WITH CATHETER-ASSOCIATED URINARY TRACT INFECTION (CA-UTI) AND LABORATORY-CONFIRMED CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTION (CLABSI)

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Antimicrobial resistance (AMR) has a major impact on healthcare, being associated with worse clinical outcomes and higher hospital costs.
Matheus Negri Boschiero, Josiane Trevisol Leal, Kenzo Sano Shine, Magda Machado de Miranda Costa, Maria Dolores Santos da Purificação Nogueira, Mara Rúbia Santos Gonçalves, Lilian de Souza Barros, Luciana Silva da Cruz de Oliveira, Ana Cristina Gales   +8 more
doaj   +1 more source

An engineered epididymal cell line provides a sustainable source of functional extracellular vesicles for in vitro sperm preservation: A multi‐omics and functional study

VIEW, EarlyView.
ABSTRACT This study investigated the function of epididymal extracellular vesicles (EVs) in overcoming sperm post‐testicular modification deficiencies. Although EVs derived from the epididymis play a crucial role in intercellular communication and molecular exchange, there is limited research addressing how EVs released by in vitro cultured epididymal ...
Long Li, Haonan Zhao, Yibo Li, Qixin Xu, Yang Zi, Tingting Chu, Heran Cao, Shujuan Liu, Zifang Wu, Huanqiang Zhao, Wuzi Dong   +10 more
wiley   +1 more source

Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria

mBio, 2017
Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance.
Fernando Baquero, José-Luis Martínez
doaj   +1 more source

Cell membrane‐coated nanoparticles for dermatological diseases

VIEW, EarlyView.
Skin disorders are challenging to treat due to complex barrier functions and limited conventional therapies. Biomimetic cell membrane‐coated nanoparticles (CM‐NPs) offer a superior nanomedicine approach by evading immune detection and enabling precise targeting.
Shuaijun Zou, Baojie Zhang, Yuanjie Zhu
wiley   +1 more source

Antimicrobial Peptides for Gram-Negative Sepsis: A Case for the Polymyxins [PDF]

, 2012
This is the publisher's version, also available electronically from "http://journal.frontiersin.org".No abstract ...
Sunil A. David
core   +2 more sources

Twin‐compartment solid–liquid cells for neutron reflectometry

Journal of Applied Crystallography, EarlyView.
We introduce a twin‐compartment solid–liquid cell for neutron reflectometry that divides a single substrate into two independent measurement areas, doubling sample capacity and enabling direct side‐by‐side comparisons. This sample environment also reduces alignment and sample preparation time and has been successfully tested on both vertical and ...
Nicoló Paracini, Hannah Burrall, Thomas Saerbeck, Philipp Gutfreund, Giovanna Fragneto, Luke A. Clifton, Thomas Arnold, Marité Cárdenas   +7 more
wiley   +1 more source