Results 11 to 20 of about 15,147 (259)

Molecular epidemiology of mcr gene group [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2020
Colistin and polymyxin B are the “last reserve” antimicrobials for the treatment of extensively drug-resistant Gram-negative bacterial infections. The rapidly increasing prevalence of polymyxin resistance mediated by the mcr gene localized on plasmid DNA
Shedko E.D., Timoshina O.Yu., Azyzov I.S.   +2 more
doaj   +1 more source

Glucose Induces Resistance to Polymyxins in High-Alcohol-Producing Klebsiella pneumoniae via Increasing Capsular Polysaccharide and Maintaining Intracellular ATP

Microbiology Spectrum, 2023
High-alcohol-producing K. pneumoniae (HiAlc Kpn) causes nonalcoholic fatty liver disease (NAFLD) by producing excess endogenous alcohol in the gut of patients with NAFLD, using glucose as the main carbon source.
Zheng Fan, Tongtong Fu, Hongbo Liu, Zhoufei Li, Bing Du, Xiaohu Cui, Rui Zhang, Yanling Feng, Hanqing Zhao, Guanhua Xue, Jinghua Cui, Chao Yan, Lin Gan, Junxia Feng, Ziying Xu, Zihui Yu, Ziyan Tian, Zanbo Ding, Jinfeng Chen, Yujie Chen, Jing Yuan   +20 more
doaj   +1 more source

Structures of Polymyxin B2 and Polymyxin E1 [PDF]

Nature, 1964
IN a previous communication1, from the analysis of a partial acid hydrolysate, the structure of polymyxin E1 was shown to be limited to two alternatives, the so-called 7 α and 8γ formulae. By applying the enzyme method of hydrolysis as devised by Suzuki et al. in their determinations of the structures of polymyxin B1 (ref. 2) and colistin A (ref.
S, WILKINSON, L A, LOWE
openaire   +3 more sources

Clinical efficacy and safety of polymyxins based versus non-polymyxins based therapies in the infections caused by carbapenem-resistant Acinetobacter baumannii: a systematic review and meta-analysis

BMC Infectious Diseases, 2020
Background The prevalence of infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) is on the rise worldwide. Polymyxins are considered as last-resort drugs for CRAB infections, but there is still controversy regarding the efficacy and ...
Cheng Lyu, Yuyi Zhang, Xiaofen Liu, Jufang Wu, Jing Zhang   +4 more
doaj   +1 more source

Bio-inspired coating strategies for the immobilization of polymyxins to generate contact-killing surfaces [PDF]

, 2016
Microbial colonization of indwelling devices remains a major concern in modern healthcare. Developing approaches to prevent biomaterial-associated infections (BAI) is, therefore, in great demand. This study aimed to immobilize two antimicrobial peptides (
Aaron, Akajagbor, Altman, Alves, Asri, Bayston, Bentzmann, Boyd, Busscher, Campoccia, Campoccia, Cirioni, Costa, del Pozo, Ding, Engelsman, Falagas, Falagas, Flemming, Gordon, Green, Gristina, Hall-Stoodley, Hasan, He, Hong, Jun, Kang, Ko, Kwa, Lee, Lim, Michalopoulos, Nation, Nijhuis, Nikaido, Oss, Oss, Paksu, Poelstra, Rodrigues, Ryder, Shah, Shalev, Slepicka, Slepicˇka, Stickler, Tart, Upton, Vogler, Wang, Yu, Zasloff, Zhou   +53 more
core   +2 more sources

Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

mBio, 2021
Colistin (polymyxin E) and polymyxin B have been used as last-resort agents for treating infections caused by multidrug-resistant Gram-negative bacteria.
Zhizeng Sun, Timothy Palzkill
doaj   +1 more source

Dissemination of MCR-Type Genes Encoding Polymyxin Resistance in Russia and Across the Globe

Антибиотики и Химиотерапия, 2021
The MCR-type polymyxin resistance gene localized on a mobile genetic element was described was described in 2015 for the first time. Publications, following the first description, demonstrated the global distribution of MCR-type genes and the role of ...
V. A. Ageevets, О. S. Sulyan, I. V. Lazareva, A. A. Sukhinin   +3 more
doaj   +1 more source

Antibiotic residues and antibiotic-resistant bacteria in pig slurry used to fertilize agricultural fields [PDF]

, 2020
Pig manure may contain antibiotic residues, antibiotic-resistant bacteria or pathogens, which may reach the environment upon fertilization. During this study, 69 antibiotic residues belonging to 12 classes were quantified in 89 pig slurry samples.
Colson, Lander, Daeseleire, Els, De Carvalho Ferreira, Helena Cardoso, Decrop, Johan, Dewulf, Jeroen, Herman, Lieve, Heyndrickx, Marc, Meirlaen, Jurgen, Rasschaert, Geertrui, Van Elst, Daan   +9 more
core   +2 more sources

The Comparative Effectiveness of Ceftolozane/Tazobactam versus Aminoglycoside- or Polymyxin-Based Regimens in Multi-Drug-Resistant Pseudomonas aeruginosa Infections

Antibiotics, 2022
Pseudomonas aeruginosa infections are challenging to treat due to multi-drug resistance (MDR) and the complexity of the patients affected by these serious infections.
Aisling R. Caffrey, Haley J. Appaneal, J. Xin Liao, Emily C. Piehl, Vrishali Lopes, Ryan J. Dillon, Laura A. Puzniak, Kerry L. LaPlante   +7 more
doaj   +1 more source

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]

, 2016
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe, Forgione, Mariantonietta, Forneris, Federico, Lucidi, Alessia, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Mehdipour, Parinaz, Pilotto, Simona, Rotili, Dante, Speranzini, Valentina, Velankar, Sameer   +11 more
core   +2 more sources