Results 21 to 30 of about 15,147 (259)

Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics

Frontiers in Microbiology, 2019
The discovery of polymyxins, highly basic lipodecapeptides, was published independently by three laboratories in 1947. Their clinical use, however, was abandoned in the sixties because of nephrotoxicity and because better-tolerated drugs belonging to ...
Martti Vaara, Martti Vaara
doaj   +1 more source

Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii [PDF]

, 2014
Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further ...
De Vos, Daniel, Kropinski, Andrew M, Lavigne, Rob, Mast, Jan, Merabishvili, Maia, Noben, Jean-Paul, Pirnay, Jean-Paul, Vandenheuvel, Dieter, Vaneechoutte, Mario, Verbeken, Gilbert   +9 more
core   +4 more sources

Shifting Gears: The Future of Polymyxin Antibiotics

Antibiotics, 2019
The manuscripts contained in this special edition of Antibiotics represent a current review of the polymyxins as well as highlights from the 3rd International Polymyxin Conference, which was held in Madrid, Spain, 25 to 26 April 2018.
Justin R. Lenhard, Zackery P. Bulman, Brian T. Tsuji, Keith S. Kaye   +3 more
doaj   +1 more source

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

Antibiotics, 2023
Polymyxins are last-line antibiotics for the treatment of Gram-negative ‘superbugs’. However, nephrotoxicity can occur in up to 60% of patients administered intravenous polymyxins. The mechanisms underpinning nephrotoxicity remain unclear.
Mengyao Li, Mohammad A. K. Azad, Philip E. Thompson, Kade D. Roberts, Tony Velkov, Yan Zhu, Jian Li   +6 more
doaj   +1 more source

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Albiol Matanic VC, Bayerl C, Berg M, Blount BW, Boguniewicz M, Bourinbaiar AS, Bradshaw J, Brogden NK, Brown JM, Carretero M, Christophers E, Ciornei CD, Conner K, Cork MJ, de Jongh GJ, Degitz K, Dempsey CE, Dubos RJ, Eiseman AS, Epand RF, Erdag G, Escher N, Falagas ME, Ge Y, Giacometti A, Glaser R, Gläser R, Gregory SM, Grossgebauer K, Guarna M, Guiliani A, Guttman-Yassky E, Hancock RE, Harder J, Harder J, Harder J, Hartmann D, Howell MD, Huttner KM, Imura Y, Jacob L, Jacobsen F, Jung K, Khandelia H, Koch-Weser J, Koczulla R, Korting HC, Kotlan B, Kretschmar M, Kretschmar M, Kretschmar M, Kreuter A, Kruse T, Lai Y, Lai YP, Lande R, Li Q, Lind HE, Liu AY, Madsen P, Mallow EB, Marincola FM, Maroti G, Melo MN, Mogi T, Muramatsu I, Nagy I, Nijnik A, Nomura I, Nussenblatt RB, Ong PY, Oono T, Pivarcsi A, Plebani M, Reddy KVR, Reddy KVR, Rieg S, Risso A, Ruckdeschel G, Rudolph B, Sader HS, Schauber J, Schauber J, Schittek B, Schittek B, Schneider JJ, Schröder JM, Schön MP, Seoh SA, Shai Y, Sigurdadottir T, Simmaco M, Steinstraesser L, Steinstraesser L, Steinstraesser L, Storm DR, Svinarich DM, Tang YQ, Voigt HU, Wang G, Wang Z, Willenberg W, Yamasaki K, Yamasaki K, Zairi A, Zanger P, Zasloff M   +106 more
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Escenario actual de la resistencia a la colistina mediada por plásmidos en América Latina [PDF]

, 2019
Colistin resistance can occur by chromosomal mutations and by acquisition of plasmid-carrying determinants, mainly mcr-1. In the recent years, we have observed the outburst of this resistance gene in our region. Due to the risk of the rapid dissemination
Di Conza, José Alejandro, Nastro, Marcela, Quiroga, Cecilia   +2 more
core   +1 more source

Identification of Genes Required for Resistance to Peptidomimetic Antibiotics by Transposon Sequencing

Frontiers in Microbiology, 2020
Pseudomonas aeruginosa is an opportunistic human pathogen and a leading cause of nosocomial infections. Due to its high intrinsic and adaptive resistance to antibiotics, infections caused by this organism are difficult to treat and new therapeutic ...
Alessandra Vitale, Gabriella Pessi, Matthias Urfer, Hans H. Locher, Katja Zerbe, Daniel Obrecht, John A. Robinson, Leo Eberl   +7 more
doaj   +1 more source

Global burden of colistin-resistant bacteria : mobilized colistin resistance genes study (1980-2018) [PDF]

, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat.
Elbediwi, Mohammed, Fang, Weihuan, Feng, Youjun, Li, Xiaoliang, Li, Yan, Pan, Hang, Paudyal, Narayan, Rajkovic, Andreja, Rankin, Shelley C., Xie, Shaohua, Yue, Min   +10 more
core   +1 more source

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria [PDF]

, 2014
Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections.
Morand, Serge, Olaitan, Abiola Olumuyiwa, Rolain, Jean-Marc   +2 more
core   +3 more sources

Polymyxins–Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment

Antioxidants, 2020
The emergence of antimicrobial resistance in Gram-negative bacteria poses a huge health challenge. The therapeutic use of polymyxins (i.e., colistin and polymyxin B) is commonplace due to high efficacy and limiting treatment options for multidrug ...
Chongshan Dai, Yang Wang, Gaurav Sharma, Jianzhong Shen, Tony Velkov, Xilong Xiao   +5 more
doaj   +1 more source