Antibiotics, 2023 Antibiotic resistance caused by multidrug-resistant (MDR) bacteria is a major challenge to global public health. Polymyxins are increasingly being used as last-in-line antibiotics to treat MDR Gram-negative bacterial infections, but resistance ...
Van C. Thai +3 more
doaj +1 more source
Cation Concentration Variability of Four Distinct Mueller-Hinton Agar Brands Influences Polymyxin B Susceptibility Results [PDF]
, 2012 Polymyxins have been the only alternative therapeutic option for the treatment of serious infections caused by multidrug-resistant Acinetobacter baumannii or Pseudomonas aeruginosa isolates.
Bispo, Paulo J. M. +3 more
core +2 more sources
Review of the international consensus guidelines for the optimal use of the polymyxins [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2019 Polymyxins are often the only agents that remain in vitro active against extensively resistant bacterial pathogens. However, the use of polymyxins is compromised by the number of unresolved issues, including the technical aspects of antimicrobial ...
Eliseeva E.V. +2 more
doaj +1 more source
Antibiotics, 2023 The global rise in antibiotic resistance in bacteria poses a major challenge in treating infectious diseases. Polymyxins (e.g., polymyxin B and colistin) are last-resort antibiotics against resistant Gram-negative bacteria, but the effectiveness of ...
Shakeel Shahzad +2 more
doaj +1 more source
Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]
, 2013 Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown +27 more
core +2 more sources
Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain [PDF]
, 2014 Objectives: To characterise antimicrobial use (AMU) per production stage in terms of drugs, routes of application, indications, duration and exposed animals in farrow-to-finish pig farms in Spain.
Moreno Romo, Miguel A.
core +3 more sources
Nephrotoxicity and Efficacy Assessment of Polymyxin Use in 92 Transplant Patients [PDF]
, 2013 Polymyxins are old antimicrobials, discontinued for many years because of nephrotoxicity and neurotoxicity reports and reintroduced recently due to the increasing frequency of multiresistant Gram-negative bacterial infections.
Camargo, Luis Fernando A. +4 more
core +1 more source
Antibiotics, 2022 Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria.
David M. P. De Oliveira +18 more
doaj +1 more source
Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum [PDF]
, 2017 In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm susceptibility on biotic surfaces, using a
Coenye, Tom +11 more
core +1 more source
Rapid polymyxin NP test for the detection of polymyxin resistance mediated by the MCR-1/MCR-2 genes [PDF]
, 2018 The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR- 1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains ...
Decousser, Jean-Winoc +6 more
core +1 more source