Results 11 to 20 of about 43,981 (239)

Identification of genes potentially regulated by human polynucleotide phosphorylase (hPNPase old-35) using melanoma as a model. [PDF]

open access: yesPLoS ONE, 2013
Human Polynucleotide Phosphorylase (hPNPase(old-35) or PNPT1) is an evolutionarily conserved 3'→ 5' exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and ...
Upneet K Sokhi   +8 more
doaj   +6 more sources

Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni [PDF]

open access: yesFrontiers in Cellular and Infection Microbiology, 2012
Polynucleotide phosphorylase, encoded by the pnp gene, is known to degrade mRNA, mediating post-transcriptional regulation and may affect cellular functions. The role of PNPase is pleiotropic.
Nabila eHaddad   +12 more
doaj   +4 more sources

Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly [PDF]

open access: yesOpen Biology, 2012
Polynucleotide phosphorylase (PNPase) is an exoribonuclease that cleaves single-stranded RNA substrates with 3′–5′ directionality and processive behaviour.
Steven W. Hardwick   +4 more
doaj   +5 more sources

The Protein Interaction of RNA Helicase B (RhlB) and Polynucleotide Phosphorylase (PNPase) Contributes to the Homeostatic Control of Cysteine in Escherichia coli. [PDF]

open access: greenJ Biol Chem, 2015
PNPase, one of the major enzymes with 3′ to 5′ single-stranded RNA degradation and processing activities, can interact with the RNA helicase RhlB independently of RNA degradosome formation in Escherichia coli.
Tseng YT   +3 more
europepmc   +3 more sources

Structure and mechanism of Mycobacterium smegmatis polynucleotide phosphorylase. [PDF]

open access: yesRNA, 2021
Polynucleotide phosphorylase (PNPase) catalyzes stepwise phosphorolysis of the 3′-terminal phosphodiesters of RNA chains to yield nucleoside diphosphate products.
Unciuleac MC   +4 more
europepmc   +2 more sources

Activity and Function in Human Cells of the Evolutionary Conserved Exonuclease Polynucleotide Phosphorylase. [PDF]

open access: yesInt J Mol Sci, 2022
Polynucleotide phosphorylase (PNPase) is a phosphorolytic RNA exonuclease highly conserved throughout evolution. Human PNPase (hPNPase) is located in mitochondria and is essential for mitochondrial function and homeostasis. Not surprisingly, mutations in
Falchi FA, Pizzoccheri R, Briani F.
europepmc   +2 more sources

Polynucleotide phosphorylase and RNA helicase CshA cooperate in Bacillus subtilis mRNA decay. [PDF]

open access: yesRNA Biol, 2021
Polynucleotide phosphorylase (PNPase), a 3ʹ exoribonuclease that degrades RNA in the 3ʹ-to-5ʹ direction, is the major mRNA decay activity in Bacillus subtilis.
Ingle S   +5 more
europepmc   +2 more sources

Pseudomonas aeruginosa Polynucleotide Phosphorylase Controls Tolerance to Aminoglycoside Antibiotics by Regulating the MexXY Multidrug Efflux Pump. [PDF]

open access: yesAntimicrob Agents Chemother, 2021
Pseudomonas aeruginosa is an opportunistic pathogen that shows high intrinsic resistance to a variety of antibiotics. The MexX-MexY-OprM efflux pump plays an important role in bacterial resistance to aminoglycoside antibiotics.
Fan Z   +9 more
europepmc   +2 more sources

Distinctive effects of domain deletions on the manganese-dependent DNA polymerase and DNA phosphorylase activities of Mycobacterium smegmatis polynucleotide phosphorylase. [PDF]

open access: greenBiochemistry, 2013
Polynucleotide phosphorylase (PNPase) plays synthetic and degradative roles in bacterial RNA metabolism; it is also suggested to participate in bacterial DNA transactions.
Unciuleac MC, Shuman S.
europepmc   +4 more sources

Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation. [PDF]

open access: yesProc Natl Acad Sci U S A
Significance Polynucleotide phosphorylase (PNPase) is a widely conserved exoribonuclease that degrades single-stranded RNA transcripts in the 3′ to 5′ direction, forming single-nucleotide diphosphates and a short oligonucleotide product.
Miller LG   +14 more
europepmc   +2 more sources

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