Results 91 to 100 of about 3,053 (190)

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

The Polyomaviridae: Contributions of virus structure to our understanding of virus receptors and infectious entry

Virology, 2009
This review summarizes the field's major findings related to the characterization of polyomavirus structures and to the characterization of virus receptors and mechanisms of host cell invasion. The four members of the family that have received the most attention in this regard are the mouse polyomavirus (mPyV), the monkey polyomavirus SV40, and the two
Neu, U., Stehle, T., Atwood, W.
openaire   +3 more sources

Viruses in unexplained encephalitis cases in American black bears (Ursus americanus).

PLoS ONE, 2020
Viral infections were investigated in American black bears (Ursus americanus) from Nevada and northern California with and without idiopathic encephalitis.
Charles E Alex, Elizabeth Fahsbender, Eda Altan, Robert Bildfell, Peregrine Wolff, Ling Jin, Wendy Black, Kenneth Jackson, Leslie Woods, Brandon Munk, Tiffany Tse, Eric Delwart, Patricia A Pesavento   +12 more
doaj   +1 more source

Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth

Viruses, 2020
Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC).
Nnenna Nwogu, Luz E. Ortiz, Hyun Jin Kwun   +2 more
doaj   +1 more source

Identification of Capsid/Coat Related Protein Folds and Their Utility for Virus Classification [PDF]

, 2017
The viral supergroup includes the entire collection of known and unknown viruses that roam our planet and infect life forms. The supergroup is remarkably diverse both in its genetics and morphology and has historically remained difficult to study and ...
Arshan Nasir, Gustavo Caetano-Anollés
core   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

Characterization of California sea lion polyomavirus 1: Expansion of the known host range of the Polyomaviridae to Carnivora

Infection, Genetics and Evolution, 2011
The genome of a novel polyomavirus first identified in a proliferative tongue lesion of a California sea lion (Zalophus californianus) is reported. This is only the third described polyomavirus of laurasiatherian mammals, is the first of the three associated with a lesion, and is the first known polyomavirus of a host in the order Carnivora.
Marine Animal Disease Laboratory, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA ( host institution ), Wellehan, James F.X. ( author ), Rivera, Rebecca ( author ), Archer, Linda L. ( author ), Benham, Celeste ( author ), Muller, Jennifer K. ( author ), Colegrove, Kathleen M. ( author ), Gulland, Frances M.D. ( author ), St. Leger, Judy A. ( author ), Venn-Watson, Stephanie K. ( author ), Nollens, Hendrik H. ( author )   +10 more
openaire   +3 more sources

DNA and seroprevalence study of MW and STL polyomaviruses

Journal of Medical Virology, Volume 96, Issue 8, August 2024.
Abstract The clinical importance and the pathogenesis of the MW and STL polyomaviruses (PyVs) remain unclear. Our aim was to study the seroprevalence of MWPyV and STLPyV, and to examine the prevalence of viral DNA in respiratory samples and secondary lymphoid tissues. In total, 618 serum samples (0.8–90 years) were analyzed for seroprevalence.
Melinda Katona, Krisztina Jeles, Péter Takács, Eszter Csoma   +3 more
wiley   +1 more source

A viral metagenomic survey identifies known and novel mammalian viruses in bats from Saudi Arabia.

PLoS ONE, 2019
Bats are implicated as natural reservoirs for a wide range of zoonotic viruses including SARS and MERS coronaviruses, Ebola, Marburg, Nipah, Hendra, Rabies and other lyssaviruses.
Nischay Mishra, Shamsudeen F Fagbo, Abdulaziz N Alagaili, Adam Nitido, Simon H Williams, James Ng, Bohyun Lee, Abdulkareem Durosinlorun, Joel A Garcia, Komal Jain, Vishal Kapoor, Jonathan H Epstein, Thomas Briese, Ziad A Memish, Kevin J Olival, W Ian Lipkin   +15 more
doaj   +1 more source

Discovery of African bat polyomaviruses and infrequent recombination in the large T antigen in the Polyomaviridae

Journal of General Virology, 2017
(Uploaded by Plazi for the Bat Literature Project) Bat species represent natural reservoirs for a number of high-consequence human pathogens. The present study investigated the diversity of polyomaviruses (PyVs) in Zambian insectivorous and fruit bat species.
Michael, Carr, Gabriel, Gonzalez, Michihito, Sasaki, Kimihito, Ito, Akihiro, Ishii, Bernard M, Hang'ombe, Aaron S, Mweene, Yasuko, Orba, Hirofumi, Sawa   +8 more
openaire   +2 more sources