Results 21 to 30 of about 21,637 (166)

Identification of MW Polyomavirus, a Novel Polyomavirus in Human Stool [PDF]

Journal of Virology, 2012
ABSTRACT We have discovered a novel polyomavirus present in multiple human stool samples. The virus was initially identified by shotgun pyrosequencing of DNA purified from virus-like particles isolated from a stool sample collected from a healthy child from Malawi.
Erica A, Siebrasse, Alejandro, Reyes, Efrem S, Lim, Guoyan, Zhao, Rajhab S, Mkakosya, Mark J, Manary, Jeffrey I, Gordon, David, Wang   +7 more
openaire   +2 more sources

Acquisition of Human Polyomaviruses in the First 18 Months of Life

Emerging Infectious Diseases, 2015
We investigated the presence of 4 human polyomaviruses (PyVs) (WU, KI, Merkel cell, and Malawi) in respiratory specimens from a community-based birth cohort. These viruses typically were acquired when children were ≈1 year of age.
Rebecca Rockett, Seweryn Bialasiewicz, Lebogang Mhango, Jane Gaydon, Rebecca Holding, David Whiley, Stephen B. Lambert, Robert S. Ware, Michael D. Nissen, Keith Grimwood, Theo P. Sloots   +10 more
doaj   +1 more source

BK polyomavirus: emerging pathogen [PDF]

Microbes and Infection, 2012
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus.
Shauna M, Bennett, Nicole M, Broekema, Michael J, Imperiale   +2 more
openaire   +2 more sources

Single-Cell, High-Content Microscopy Analysis of BK Polyomavirus Infection

Microbiology Spectrum, 2023
By adulthood, the majority of the population is persistently infected with BK polyomavirus (BKPyV). Only a subset of the population, generally transplant recipients on immunosuppressive drugs, will experience disease from BKPyV, but those who do have few
Megan C. Procario, Jonathan Z. Sexton, Benjamin S. Halligan, Michael J. Imperiale   +3 more
doaj   +1 more source

Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers

Journal for ImmunoTherapy of Cancer
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its ...
David Schrama, Antoine Touze, Thibault Kervarrec, Mahtab Samimi, Valérie Gouilleux-Gruart, Aurelie Drouin, Laurine Durand, Clara Esnault, Pauline Gaboriaud, Valérie Leblond, Shawk Karim, Morgane Fouché, Christine Dhommée, Christine B Baltus, Fanny Boursin, Nicolas Aubrey, Roland Houben, Serge Guyétant, Audrey Desgranges, Marie Claude Viaud-Massuard   +19 more
doaj   +1 more source

Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination

Viruses, 2020
Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
doaj   +1 more source

Polyomavirus genome and polyomavirus enhancer-driven gene expression during myogenesis [PDF]

Journal of Virology, 1989
The mRNAs for myogenic functions are coordinately transcribed with polyomavirus (Py) early mRNA during in vitro differentiation of mouse C2 myoblast cells. Sequence analysis shows that the A domain of the Py enhancer includes an E1A-like consensus sequence that is also found in the 5' upstream region of two genes expressed during myoblast ...
MAIONE, Rossella, A. Felsani, L. Pozzi, M. Caruso, AMATI, Paolo   +4 more
openaire   +3 more sources

The Ancient Evolutionary History of Polyomaviruses.

PLoS Pathogens, 2016
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to ...
Christopher B Buck, Koenraad Van Doorslaer, Alberto Peretti, Eileen M Geoghegan, Michael J Tisza, Ping An, Joshua P Katz, James M Pipas, Alison A McBride, Alvin C Camus, Alexa J McDermott, Jennifer A Dill, Eric Delwart, Terry F F Ng, Kata Farkas, Charlotte Austin, Simona Kraberger, William Davison, Diana V Pastrana, Arvind Varsani   +19 more
doaj   +1 more source

Seroprevalence of Human Malawi Polyomavirus [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACT The seroprevalence of the recently discovered human Malawi polyomavirus (MWPyV) was determined by virus-like particle-based enzyme-linked immunosorbent assay (ELISA) in age-stratified Italian subjects. The findings indicated that MWPyV infection occurs early in life, and seroprevalence was shown to reach 42% in adulthood.
Jérôme TJ Nicol, Valérie Leblond, Françoise Arnold, Giovanni Guerra, MAZZONI, Elisa, TOGNON, Mauro, Pierre Coursaget, Antoine Touzé   +7 more
openaire   +4 more sources

Brincidofovir inhibits polyomavirus infection in vivo

mBio
Polyomaviruses are species-specific DNA viruses that can cause disease in immunocompromised individuals. Despite their role as the causative agents for several diseases, there are no currently approved antivirals for treating polyomavirus infection ...
Arrienne B. Butic, Zoe E. Katz, Ge Jin, Koji Fukushima, Masatoshi Hazama, Aron E. Lukacher, Matthew D. Lauver   +6 more
doaj   +1 more source