Results 91 to 100 of about 1,357 (186)

Integrated multi-omics analysis reveals the polyphyllins biosynthesis in Paris polyphylla var. yunnanensis across different growth years

Industrial Crops and Products
Growth duration significantly influences the active ingredient content of Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz, a valuable perennial Chinese medicinal herb.
Xiaoye Zhang, Jia Chen, Qi Qiang, Ping Xu, Guowei Zheng   +4 more
doaj   +1 more source

Effects of Rhizoma Parisdis total saponins and its main compounds on gastric emptying via regulating muscarinic receptors in vitro and in vivo

, 2017
The aim of this study was to explore the inhibitory effect of Rhizoma Parisdis total Saponins (RPS) and the main monomer compounds (polyphyllin I, II, VI and H) on gastric emptying and gastrointestinal motilityin vitroandin vivo.
Liying Han, Shuli Man, Yuanxue Liu, Zhen Liu, Yu Wang, Wenyuan Gao, Genbei Wang, Changxiao Liu, Ting Xia   +8 more
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Inhibition of EZH2 via activation of SAPK

, 2016
Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla , has been reported to exhibit anti-cancer activity.
Fang Zheng, Longmei Li, Qing Tang, JingJing Wu, WanYin Wu, Swei Sunny Hann   +5 more
core   +1 more source

Polyphyllin I Inhibits the Metastasis of Cervical Cancer Through the Regulation of the β-Catenin Signaling Pathway

Cervical cancer ranks as the fourth most prevalent cancer and cause of cancer-related mortality among women globally. It exhibits a recurrence/metastasis rate of approximately 30% and a dismal 5-year survival of only 17% in metastatic cases.
Yuying Zhu, Chunying Luo, Xu Wang, Rui Zhang, Shaopeng Yu, Jiange Zhang, Jiawen Peng, Guoqiang Lin, Yingbin Chai   +8 more
core   +1 more source

Antitumor effects of polyphyllin D, a steroidal saponin found in paris polyphylla, on two human breast cancer cell lines MCF-7 and MDA-MB-231. [PDF]

, 2003
Lee Mei-sze.Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.Includes bibliographical references (leaves 123-133).Abstracts in English and Chinese.ACKOWLEDGEMENT --- p.iABSTRACT --- p.iiABSTRACT in Chinese (摘要） --- p.ivLIST OF FIGURES AND ...

core  

Paris polyphylla subsp. roots

, 2018
<i>5.9. HPLC method for detecting steroid saponins in P. polyphylla roots</i> <p>For HPLC, an aliquot of the same fresh plant root material that was used for expression analysis was freeze-dried at −50 ̊C for 8 h, and then ...
Gao, Linhui, Yin, Yan, Gao, Wei, Zhang, Xianan   +3 more
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Synthesis of Active Steroidal Glycosides and Flavonoid Glycosides

, 2003
甾体皂甙和黄酮体甙是自然界广泛存在的糖缀合物，它们是许多药用植物的活性成份，具有多种生物活性。本论文完成了一系列甾体皂甙和黄酮体甙的合成和结构确定工作，为测试其生物活性、研究构效关系和药物开发奠定基础。 i)Polyphyllin D合成方法的改进： Polyphyllin D是一个具有2，4分枝的三糖甾体皂甙，它具有良好细胞毒性。以D—葡萄糖和薯蓣甙元为起始原料，经保护基操作和糖苷化反应得到关键的二醇受体15。在TMSOTf的促进下，15与Piv保护的鼠李糖三氯亚胺酯给体21反应，以71 ...
李明
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Study on Synthesis and Regulation of PPVI and PPVII in Paris polyphylla with UV

Metabolites
Paris polyphylla Smith var. Chinensis (Franch.) Hara is a medicinal plant that belongs to the Liliaceae family. Its main components are parissaponins, which have excellent medicinal effects such as anti-inflammatory, anti-tumor, etc.
Dongjie Geng, Yiqun Sun, Shouzan Liu, Wen Chen, Fei Gao, Yan Bai, Shaobo Zhang   +6 more
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Simultaneous determination of Polyphyllin I and Polyphyllin II from Rhyzoma Paridis dog plasma by a rapid HPLC and its application to pharmacokinetic study after oral administration

Journal of Medicinal Plants Research, 2012
For the first time, a rapid and specific reversed phase-high performance liquid chromatography-ultraviolet (RP-HPLC-UV) method was developed for the analysis of polyphyllin I and polyphyllin II in beagle dog plasma. The method was applied to study the pharmacokinetics of Rhizoma paridis capsule containing polyphyllin I and polyphyllin II.
openaire   +1 more source

Antitumor effect of polyphyllin I (PPI) on colorectal cancer: Evidence from patient-derived organoids and Notch signaling suppression

Heliyon
Colorectal cancer (CRC) is a malignant tumor with a high incidence, ranking first among gastrointestinal malignancies. We investigated the impact of polyphyllin I (PPI), a natural compound found in Paris polyphylla, on CRC.
Yu Wang, Hao Ge, Yi Zhang, Pei Wang, Haoran Zhao, Lu Wang, Zhimin Fan   +6 more
doaj   +1 more source