Results 101 to 110 of about 1,357 (186)

Polyphyllin VII as a potential medication for targeting epithelial mesenchymal transitionin in thyroid cancer

Journal of Pharmacological Sciences
The need for novel anti-thyroid cancer (TC) medications is urgent due to the rising incidence and metastatic rates of malignant TC. In this study, we investigated the effect of Polyphyllin VII (PPVII) to TC cells, and explored their potential mechanism.
Qingqing Yu, Jinglin Chen, Chen Zhong, Le Yu, Yunhe Zhu, Xueyan Xi, Boyu Du   +6 more
openaire   +2 more sources

Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis

Ferroptosis has been shown to mediate the development of fibrosis. Polyphyllin VII (PP7), a bioactive component of Paris polyphylla, exhibits potent anti-inflammatory activity and can significantly alleviate liver fibrosis.
Jianjian Zheng, Weizhi Zhang, Feng Jiang, Mengyuan Li, Yifei Li, Xinmiao Li, Lufan He, Lifan Lin   +7 more
core   +1 more source

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling. [PDF]

Oncol Rep
Sun J, Liang H, Zhang Y, Ding D, Xiang Q, Zheng M, Zhang P.   +6 more
europepmc   +1 more source

Preparation of doxorubicin-loaded polyphyllin H liposomes and synergistic anti-tumor activity against non-small cell lung cancer in vitro

Objective‍　‍To prepare glucose transporter 1 (Glut1) -targeted doxorubicin (DOX)-loaded liposomes (doxorubicin/polyphyllin H-liposomes, DOX/ppH-LPs) using polyphyllin H (ppH) instead of cholesterol as the liposomal membrane material, and to investigate ...
ZHOU Dawei, GAI Shouchang, LIU Yining
core   +1 more source

Corrigendum to "The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway" [J. Pharm. Anal. 13 (2023) 39<b>-</b>54]. [PDF]

J Pharm Anal
Li Z, Fan Q, Chen M, Dong Y, Li F, Wang M, Gu Y, Guo S, Ye X, Wu J, Dai S, Lin R, Zhao C.   +12 more
europepmc   +1 more source

A review of glycosylation diversity and biosynthetic advances of steroidal saponins in <i>Paris polyphylla</i> var. <i>yunnanensis</i>. [PDF]

Front Plant Sci
Luo Y, Guo R, He X, Peng A, Li L, Li H.
europepmc   +1 more source

Polyphyllin I alleviates neuroinflammation after cerebral ischemia–reperfusion injury via facilitating autophagy-mediated M2 microglial polarization

Microglial activation and polarization play a central role in poststroke inflammation and neuronal damage. Modulating microglial polarization from pro-inflammatory to anti-inflammatory phenotype is a promising therapeutic strategy for the treatment of ...
Jia Li, Xiaoyang Liu, Dingxi Liu, Chunyang Kang, Qiuling Sang, Libo Wang   +5 more
core   +1 more source

Multi-dimensional identification and quality evaluation of <i>Paris polyphylla</i> cultivated populations using morphological, molecular, cytological and metabolic traits. [PDF]

Front Plant Sci
Jiang J, Qin Y, Yu Z, Chen J, Wang J, Yang S, Liu Y, Liu T.   +7 more
europepmc   +1 more source

Polyphyllin II attenuates renal fibrosis in diabetic kidney disease partly through regulation of autophagy and PI3K/AKT/mTOR signaling. [PDF]

Front Pharmacol
Sun X, Qin X, Bi H.
europepmc   +1 more source

Endoplasmic reticulum stress reduces caspofungin resistance in <i>Cryptococcus neoformans</i>. [PDF]

mSphere
Qu X, Hu G, Lee CWJ, Horianopoulos L, Kronstad JW.   +4 more
europepmc   +1 more source