Results 141 to 150 of about 1,853 (164)

Diverse binding site structures revealed in homology models of polyreactive immunoglobulins

Journal of Computer-Aided Molecular Design, 1997
We describe here computer-assisted homology models of the combining site structure of three polyreactive immunoglobulins. Template-based models of Fv (VL-VH) fragments were derived for the surface IgM expressed by the malignant CD5 positive B cells from three patients with chronic lymphocytic leukaemia (CLL).
P A, Ramsland   +3 more
openaire   +3 more sources

[Properties of polyreactive immunoglobulins].

Ukrainskii biokhimicheskii zhurnal (1978), 1994
Some biological properties of polyreactive antibodies (PRABs) from the serum of mice, rabbit and cattle are investigated. Optimal parameters of the activation process are determined. It is shown that solution of KSCN (potassium rhodanide) more effectively impedes interaction of PRABs with the antigen on the immunological plate than interaction between ...
S A, Bobrovnik, A V, Marinets
openaire   +1 more source

[Ligand-induced structuring of polyreactive immunoglobulins].

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2004
The influence of several hydrophobic compounds with different structures on the binding of native and chaotropically modified bovine immunoglobulins to native and denatured nonspecific protein immobilized on the surface is researched. It is shown that the character of binding depends on the amount and mutual location of hydrophobic nuclei in the ...
L V, Il'ina, S V, Verevka
openaire   +1 more source

[Transformation of serum immunoglobulins to polyreactive antibodies].

Ukrainskii biokhimicheskii zhurnal (1978), 1998
In order to elucidate the mechanism of induction of serum immunoglobulins polyreactive properties by chaotropic ions, gel-chromatography of immunoglobulins in the medium containing 3.3 M KSCN, has been done. It was found that the transformation of serum immunoglobulins to polyreactive antibodies, which could react with different serological unrelated ...
S A, Bobrovnik   +2 more
openaire   +1 more source

Polyreactive Transformation of Class G Immunoglobulins as a Vector for Search of Potential Means for Improving the Activity of Anti-endotoxin Immunity

Human Physiology, 2020
Short-term in vitro exposure of a chaotropic reagent to native class G immunoglobulins can significantly increase the activity of anti-endotoxin immunity and cause a decrease in the ability of effector cells for enterobacteria lipopolysaccharides (LPS). This leads to reducing the LPS-dependent activation of these cells and subsequent inflammation. This
A. I. Gordienko   +4 more
openaire   +1 more source

The urodele amphibian Pleurodeles waltl has a diverse repertoire of immunoglobulin heavy chains with polyreactive and species-specific features

Developmental & Comparative Immunology, 2015
Urodele amphibians are an interesting model because although they possess the cardinal elements of the vertebrate immune system, their immune response is apparently subdued. This phenomenon, sometimes regarded as a state of immunodeficiency, has been attributed by some authors to limited antibody diversity.
Coralie, Fonte   +3 more
openaire   +2 more sources

[Complement-binding and immuno-modulating properties of polyreactive immunoglobulins].

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2004
New data concerning biological properties of polyreactive immunoglobulins (PRIG) were obtained as a result of treatment of mouse serum immunoglobulins by 4 M KSCN and are presented in the paper. In particular, the capacity of PRIG to bind C1q, the subunit of the first component of complement was studied. It was shown that PRIG's binding capacity to C1q
S A, Bobrovnik   +3 more
openaire   +1 more source

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