Results 51 to 60 of about 1,853 (164)

Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
ABSTRACT The alpha‐Gal syndrome (AGS) is an underdiagnosed tick‐borne allergy characterized by both immediate and delayed IgE‐mediated anaphylactic reactions to the galactose‐alpha‐1,3‐galactose (alpha‐Gal) epitope. Common manifestations include gastrointestinal, cutaneous, and respiratory symptoms appearing 2–6 h after the consumption of mammalian ...
Rita Vaz‐Rodrigues, José de la Fuente
wiley   +1 more source

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. [PDF]

, 2012
Antineutrophil cytoplasmic antibodies (ANCAs) target proteins normally retained within neutrophils, indicating that cell death is involved in the autoimmunity process. Still, ANCA pathogenesis remains obscure.
Abdgawad, Alcorta, Barbara Cappetti, Bennett, Bianchi, Brinkmann, Carla Guarnotta, Cassatella, Caterina Vitali, Chin, Claudia Chiodoni, Claudio Tripodo, Clayton, Colombo, Cristiana Guiducci, Di Carlo, Dittmar, Donnelly, Drenkard, Falk, Fuchs, Gaipl, Galeazzi, Garcia-Romo, Gilligan, Griffith, Guiducci, Jarius, Kantari, Kessenbrock, Lande, Manolova, Mariella Parenza, Mario P. Colombo, Martinelli, Metzler, Munafo, Nagata, Nathan, Patrizia Casalini, Patry, Potter, Pradhan, Remijsen, Sabina Sangaletti, Sangaletti, Santiago-Raber, Silvia Piconese, Specks, Spronk, Steinman, Tripodo, van der Geld, van Timmeren, Villanueva, Wernick, Witko-Sarsat, Ziegler-Heitbrock   +57 more
core   +1 more source

B Cells Expressing a Natural Polyreactive Autoantibody Have a Distinct Phenotype and Are Overrepresented in Immunoglobulin Heavy Chain Transgenic Mice [PDF]

The Journal of Immunology, 2006
Abstract Despite stringent regulation of disease-associated autoantibodies, a substantial proportion of circulating Abs in sera of healthy individuals exhibit self-reactivity. These Abs are referred to as naturally occurring or natural autoantibodies (NAAs).
Qi, Tian, Michael, Beardall, Yang, Xu, Ju, Li, David C, Parker, Nina, Casanova, Anthony C, Bakke, Ching, Chen   +7 more
openaire   +2 more sources

Maternal IgE Influence on Fetal and Infant Health

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla, Abhay P. S. Rathore, Ashley L. St. John   +2 more
wiley   +1 more source

Влияние полиреактивных иммуноглобулинов сыворотки крови на определение аффинности сывороточных антител [PDF]

, 2010
Наличие в сыворотках животныx полиреактивных иммуноглобулинов может заметно повлиять на точность определения константы равновесия реакции взаимодействия специфичных антител и соответствующего антигена.
Бобровник, С.А., Демченко, М.А., Комисаренко, С.В.   +2 more
core  

Self‐reactive B cells are increased in all major stages of peripheral development in Sjögren's disease

Immunology &Cell Biology, Volume 103, Issue 4, Page 401-410, April 2025.
In this article, we identify self‐reactive peripheral blood B cells in Sjögren's disease through a single‐cell culture system. We find 2‐ to 10‐fold increased frequencies of self‐reactive B cells during all stages of peripheral development in Sjögren's compared with healthy donors.
Adrian YS Lee, Zhankun Qi, Katherine JL Jackson, Joanne H Reed   +3 more
wiley   +1 more source

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse [PDF]

, 2009
Natural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown.
A Coutinho, AB Pernis, AF Ochsenbein, AH Mansur, AM Oliver, B Falini, B Srivastava, C Penha-Gonçalves, CA Barbosa, D Holmberg, E Lander, ER Bleecker, F Martin, F Martin, FJ Grundbacher, HK Parmentier, HP Vollmers, HW Mittrucker, IB Borecki, J Côrte-Real, J Demengeot, J Garcia, J Rodo, JB Chung, JC Fanzo, JJ Manson, JR Tumang, JS Brown, KC Barnes, KJ Livak, KL Calame, KW Broman, L Lin, LA Herzenberg, LA Herzenberg, M Boes, M Boes, M Boes, M Boes, M Haury, M Shapiro-Shelef, MR Ehrenstein, MR Ehrenstein, N Baker, N Nishiya, NA Bos, NJ Lee, NM Kachamakova, P Almeida, P Pereira, PM Lydyard, R Gobet, R Lu, R Sciammas, RR Hardy, S Brandlein, S Lacroix-Desmazes, S Marecki, U Klein, Y Mamane, Y Peng   +60 more
core   +1 more source

Common idiotypes expressed on human, monoclonal, abnormal immunoglobulins and cryoglobulins with polyreaetive autoantibody activities [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYSeveral hutiian monoclonal immunoglobtilins with the same auloatitibody activity have been shown to have cross-reactive idiotypes (CRI). In this study, using polyclonal anti-idiotypic antibodies, we fotind that 28% of hutnan monoclonal immunoglobulins with polyreaetive autoantibody activity from myeloma.
M R, Barbouche, B, Guilbert, S, Makni, Y, Gorgi, K, Ayed, S, Avrameas   +5 more
openaire   +2 more sources

Intestinal mucosal immunity and type 1 diabetes: Non‐negligible communication between gut and pancreas

Diabetes, Obesity and Metabolism, Volume 27, Issue 3, Page 1045-1064, March 2025.
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T cell‐mediated pancreatic β cell loss, resulting in lifelong absolute insulin deficiency and hyperglycaemia. Environmental factors are recognized as a key contributor to the development of T1D, with the gut serving as a primary interface for environmental stimuli.
Ruonan Liu, Jing Zhang, Si Chen, Yang Xiao, Jingyi Hu, Zhiguang Zhou, Lingxiang Xie   +6 more
wiley   +1 more source

Know Your ABCs: Discovery, Differentiation, and Targeting of T‐Bet+ B Cells

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Since their first description in 2008, T‐bet+ B cells have emerged as a clinically important B cell subset. Now commonly known as ABCs (Age‐associated B Cells), they are uniquely characterized by their expression of the transcription factor T‐bet. Indeed, this singular factor defines this B cell subset.
Gary M. Winslow, Russell Levack
wiley   +1 more source