Results 61 to 70 of about 1,853 (164)
Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond. [PDF]
, 2012 International audienceABSTRACT: The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists ...
A Bosma +154 more
core +5 more sources
Signaling Activation and Modulation in Extrafollicular B Cell Responses
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT The differentiation of naive follicular B cells into either the germinal center (GC) or extrafollicular (EF) pathway plays a critical role in shaping the type, affinity, and longevity of effector B cells. This choice also governs the selection and survival of autoreactive B cells, influencing their potential to enter the memory compartment ...
Julian Staniek, Marta Rizzi
wiley +1 more source
Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age [PDF]
, 2017 The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated ...
Britt G Jong +7 more
core +2 more sources
Oxidation-Specific Epitopes (OSEs) Dominate the B Cell Response in Murine Polymicrobial Sepsis [PDF]
, 2020 In murine abdominal sepsis by colon ascendens stent peritonitis (CASP), a strong increase in serum IgM and IgG antibodies was observed, which reached maximum values 14 days following sepsis induction. The specificity of this antibody response was studied
Berek, Claudia +10 more
core +1 more source
Nanobody engineering: computational modelling and design for biomedical and therapeutic applications
FEBS Open Bio, Volume 15, Issue 2, Page 236-253, February 2025.This review focuses on structural characteristics, functional properties, and computational approaches driving the design and optimisation of synthetic nanobodies. We discuss recent advancements in computational methods for nanobody modelling, epitope prediction, and affinity maturation, shedding light on their intricate antigen‐binding mechanisms and ...
Nehad S. El Salamouni +3 more
wiley +1 more source
Follicular lymphoma research: an open dialogue for a collaborative roadmap
Histopathology, Volume 86, Issue 1, Page 79-93, January 2025.In this review we discuss the gaps in the current follicular lymphoma (FL) in terms of diagnosis and understanding of the underlying functional biology that can predict clinical course and response to therapy. This review intends to be a first step and an interactive platform to a collaborative roadmap towards better understanding and care of FL ...
Mélanie Collin +6 more
wiley +1 more source
Immunoglobulin A Antibodies: From Protection to Harmful Roles
Immunological Reviews, Volume 328, Issue 1, Page 171-191, November 2024.ABSTRACT Immunoglobulin A (IgA) is the most abundantly produced antibody in humans. IgA is a unique class of immunoglobulin due to its multiple molecular forms, and a defining difference between the two subclasses: IgA1 has a long hinge‐region that is heavily O‐glycosylated, whereas the IgA2 hinge‐region is shorter but resistant to bacterial proteases ...
Patrick J. Gleeson +4 more
wiley +1 more source
Chronic Lymphocytic Leukemia: Insights from Lymph Nodes & Bone Marrow and Clinical Perspectives [PDF]
, 2010 B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly variable distribution of tumor mass between peripheral blood, bone marrow and lymphoid organs which is important for staging, classification and prognosis.
Branimir Jakšić +2 more
core +1 more source
European Journal of Immunology, Volume 54, Issue 10, October 2024.The authors developed a novel blocking of binding (BoB)‐ELISA to accurately estimate the titers of serum antibodies targeting distinct influenza hemagglutinin (HA) epitopes. Leveraging BoB‐ELISA, the authors found that serum antibodies targeting the HA head epitopes were immunodominant, whereas antibodies against the stem epitope, although subdominant,
Philipp C. G. Paparoditis +12 more
wiley +1 more source
Antibody Engineering for Pursuing a Healthier Future [PDF]
, 2017 Since the development of antibody-production techniques, a number of immunoglobulins have been developed on a large scale using conventional methods. Hybridoma technology opened a new horizon in the production of antibodies against target antigens of ...
Abdullah F. U. H. Saeed +3 more
core +1 more source