Results 1 to 10 of about 2,499 (191)

Enantioseparation of 5,5′-Dibromo-2,2′-dichloro-3-selanyl-4,4′-bipyridines on Polysaccharide-Based Chiral Stationary Phases: Exploring Chalcogen Bonds in Liquid-Phase Chromatography [PDF]

Molecules, 2021
The chalcogen bond (ChB) is a noncovalent interaction based on electrophilic features of regions of electron charge density depletion (σ-holes) located on bound atoms of group VI.
Paola Peluso, Alessandro Dessì, Roberto Dallocchio, Barbara Sechi, Carlo Gatti, Bezhan Chankvetadze, Victor Mamane, Robin Weiss, Patrick Pale, Emmanuel Aubert, Sergio Cossu   +10 more
doaj   +2 more sources

Possibilities and limitations of computer assisted chiral HPLC method development for ozanimod on polysaccharide based chiral stationary phases [PDF]

Scientific Reports
In this study, a direct HPLC method was developed to determine the enantiomeric purity of the immunomodulatory drug, ozanimod. A systematic method development process was followed, incorporating risk assessment, identification of critical analytical ...
Elek Ferencz, Zoltán-István Szabó, Arnold Zöldhegyi, Gergely Dombi, Gergely Molnár, Máté Dobó, Erzsébet Varga, Imre Molnár, Gergő Tóth   +8 more
doaj   +2 more sources

A Design of Experiments-Based Chiral HPLC Method for the Quantification of Talazoparib and Enantiomeric Purity Determination in Pharmaceutical Formulations. [PDF]

Chirality
A design of experiments–based chiral HPLC method was developed for the enantiomeric separation and quantification of talazoparib in pharmaceutical formulations. Efficient resolution of the enantiomers (RS > 7) was achieved within 12 min. The method was validated and successfully applied to tablet analysis, and its environmental sustainability was ...
Atila Karaca S, Aliyeva S, Yeniceli D.
europepmc   +2 more sources

Quantum Chemistry Based Simulation of Enantioseparation on Cyclodextrin- and Polysaccharide-Based Chiral Stationary Phases. [PDF]

Chemistry
We employed a systematic quantum chemistry‐based computational approach for simulating chiral HPLC, incorporating high‐level DFT methods. For the popular polysaccharide‐based CSPs, 90%$\%$ of determined elution orders were computed correctly. Abstract We assess the capability of modern quantum chemical methods to simulate enantioseparation on chiral ...
Nelles-Ziegler L, Plett C, Grimme S.
europepmc   +2 more sources

Stereoisomeric Separation of Flavonoids by Two-Dimensional Supercritical Fluid Chromatography: Identification of Adequate Chiral Columns and Application to Honey Analysis. [PDF]

Chirality
The best enantioselective stationary phases to resolve chiral flavonoids were identified. Two‐dimensional heart‐cut supercritical fluid chromatography (SFC‐SFC) was used to isolate and resolve the enantiomers of pinocembrin from a complex sample of honey.
Réset L, Ousseni B, Degrelle M, Jores CS, West C.   +4 more
europepmc   +2 more sources

Nonideal behavior of void volume markers in polar-organic chiral HPLC on polysaccharide-based chiral stationary phases. [PDF]

J Liq Chromatogr Relat Technol, 2021
Polysaccharide-based chiral stationary phases account for a majority of chiral HPLC separations. Their behavior in normal-phase and reversed-phase modes of separation has been studied extensively. However, much less is known about their behavior in polar-organic mode.
Krivoshein AV, Hu Z.
europepmc   +3 more sources

New Levan-Based Chiral Stationary Phases: Synthesis and Comparative HPLC Enantioseparation of (±)-trans-β-Lactam Ureas in the Polar Organic Mode [PDF]

Molecules
In this paper, the preparation of three new polysaccharide-type chiral stationary phases (CSPs) based on levan carbamates (3,5-dimethylphenyl, 4-methylphenyl, and 1-naphthyl) is described.
Darko Kontrec, Mladenka Jurin, Andreja Jakas, Marin Roje   +3 more
doaj   +2 more sources

Optimization of Liquid Crystalline Mixtures Enantioseparation on Polysaccharide-Based Chiral Stationary Phases by Reversed-Phase Chiral Liquid Chromatography. [PDF]

Int J Mol Sci
Enantioseparation of nineteen liquid crystalline racemic mixtures obtained based on (R,S)-2-octanol was studied in reversed-phase mode on an amylose tris(3-chloro-5-methylphenylcarbamate) (ReproSil Chiral-MIG) and a cellulose tris(3,5-dichlorophenylcarbamate) (ReproSil Chiral-MIC).
Urbańska M.
europepmc   +3 more sources

Enantioselective Properties of Neglected Drug Nifurtimox on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases by Green HPLC Separation Methods. [PDF]

J Sep Sci
ABSTRACT Nifurtimox (NFX) is a chiral drug used for the treatment of Chagas Disease. Little attention has been paid to the enantioselective properties of chiral drugs used for neglected tropical diseases, highlighting the need for further studies in this area.
Mohr A, Segala É, Machado das Neves G, Eifler-Lima VL, Steppe M.   +4 more
europepmc   +2 more sources

Monosaccharide-Derived Enantioselectivity in SWCNT Chemoresistive VOC Sensing. [PDF]

Chemistry
Enantioselective sensing of minimally functionalized chiral VOCs with common recognition layers remains challenging. A chemoresistive sensor based on semiconducting single‐walled carbon nanotubes modified with multichiral and multifunctional substituted monosaccharides displays intriguing chiral preference toward (–)‐limonene and (–)‐carvone ...
Shitrit A, Sukhran Y, Tverdokhleb N, Chen L, Dianat A, Gutierrez R, Körbel S, Croy A, Cuniberti G, Hurevich M, Yitzchaik S.   +10 more
europepmc   +2 more sources