Results 41 to 50 of about 234,964 (312)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review

, 2014
Polysaccharides and their derivatives are increasingly being used by the food, cosmetic and pharmaceutical industries: physical properties like size and conformation are important contributors to their performance. Here the use of hydrodynamic tools such
Harding, Stephen E., Adams, G. G., Morris, Gordon, Morris, Gordon A., Adams, Gary G., Harding, S. E.   +5 more
core   +1 more source

Precision native polysaccharides from living polymerization of anhydrosugars

, 2023
The composition, sequence, length, and type of glycosidic linkages of polysaccharides profoundly affect their biological and physical properties. However, investigation of the structure-function relationship of polysaccharides is hampered by accessing ...
Lianqian, Wu, Shoshana, Reich, Junpeng, Wang, Jia, Niu, Zhensheng, Zhao, Devavrat, Sathe, Zefeng, Zhou, Junfeng, Zhou   +7 more
core   +1 more source

Effect of Soluble Dietary Fiber of Navel Orange Peel Prepared by Mixed Solid-State Fermentation on the Quality of Jelly

Foods, 2023
The aim of this work was to prepare soluble dietary fibers (SDFs) from insoluble dietary fiber of navel orange peel (NOP-IDF) by mixed solid-state fermentation (M-SDF) and to investigate the influence of fermentation modification on the structural and ...
Yanan Cheng, Puyou Xue, Yi Chen, Jianhua Xie, Guanyi Peng, Shenglan Tian, Xinxin Chang, Qiang Yu   +7 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Dietary inulin modulates pork quality and systemic health via gut microbiome and metabolome changes in finishing pigs

Animal Microbiome
Background Inulin is widely recognized for its ability to improve glucolipid metabolism and modulate the gut microbiome and metabolome. However, the potential to influence pork flavor development through gut environment changes in animal husbandry ...
Yunpeng Wang, Kayeon Ko, Eunyoung Kim, Miroslava Kačániová, Yunkyoung Lee, Guiguo Zhang   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes [PDF]

, 2011
Glycosaminoglycans (GAGs) are polysaccharides that are typically present in a wide diversity of animal tissue. Most common GAGs are well-characterized and pharmaceutical applications exist for many of these compounds, e.g. heparin and hyaluronan.
Kengen, S.W.M., Servé W. M. Kengen, van der Oost, J., Oost, J., van der, Raedts, J.G.J., John van der Oost, John Raedts   +6 more
core   +1 more source

Polysaccharides from fermented coix seed modulates circulating nitrogen and immune function by altering gut microbiota

Current Research in Food Science, 2022
Coix lachryma-jobi L. seed is an important food item in Asia with culinary and medicinal values. The effects of non-fermented coix seed (NFC), fermented coix seed with Lactobacillus plantarum NCU137 (FC) and polysaccharides from NFC, FC (FCP) on mice ...
Hui Wang, Hongmei Yin, Yadong Zhong, Jielun Hu, Shengkun Xia, Zixuan Wang, Shaoping Nie, Mingyong Xie   +7 more
doaj   +1 more source