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Lonophoric Properties of Polysorbate 80
Journal of Pharmaceutical Sciences, 1986Polysorbate 80, a surfactant often assumed to be inert, was found to bind a number of biochemically important ions (K+, Na+, NH4+, Ca2+) and transport them through a model membrane (CH2Cl2). The rates and fluxes of potassium ions were found to depend on the initial concentration of potassium ion, the polysorbate 80 concentration, the temperature, and ...
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Rational design to biologics development: The polysorbates point of view
International Journal of Pharmaceutics, 2020Stane Pajk, Janez Mravljak
exaly
Polysorbate Degradation and Quality
2018Among many other applications, polysorbates (PSs) are used as the most common surfactants in biopharmaceutical products in particular to protect proteins against interfacial stress. Structural heterogeneity, presence of degradants and other impurities, and tendency for degradation are interrelated features found in commercial PSs with a direct impact ...
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Degradation of polysorbates 20 and 80 catalysed by histidine chloride buffer
European Journal of Pharmaceutics and Biopharmaceutics, 2020Stane Pajk, Janez Mravljak
exaly
Using Polysorbates to Create Parenteral Dosage Forms of Hydrophobic Substances (A Review)
Pharmaceutical Chemistry Journal, 2022L L Nikolaeva
exaly