Results 81 to 90 of about 1,949 (187)

Personalization and Fortification of In‐Space Manufactured Emulsified Beverages for Long‐Term Space Travel

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT The current trend of individualized food items (nutrient content and flavor) can be particularly valuable to support people's health and well‐being in isolated environments where access to fresh foods and diverse nutrition is difficult. At the same time, bioactive compounds and micronutrients can be employed to countermeasure any health ...
Svenja Schmidt   +4 more
wiley   +1 more source

Anaphylaxis and the inclusion of polysorbates in biotherapeutics

open access: yesJournal of Excipients and Food Chemicals, 2017
Both unwanted immunogenicity and anaphylaxis comprise major components of safety assessment, however, few if any attempts are made to differentiate drug-related from excipient-related anaphylaxis.
Edward Maggio
doaj  

Intravitreal injection of polysorbate 80: a functional and morphological study

open access: yesRevista do Colégio Brasileiro de Cirurgiões
Objective : to determine the functional and morphological effects at rabbits retina of PS80 concentration used in the preparation of intravitreal drugs. Methods: eleven New Zealand rabbits received a intravitreal injection of 0.1ml of PS80.
FRANCISCO MAX DAMICO   +8 more
doaj   +1 more source

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li   +11 more
wiley   +1 more source

Prospective Trial on Tolerability and Efficacy of Adjuvant Nedaplatin Plus Docetaxel for Non‐Small Cell Lung Cancer

open access: yesCancer Science, Volume 117, Issue 9, Page 2535-2542, September 2026.
The flow of this trial and the treatment schedule of adjuvant chemotherapy with nedaplatin plus docetaxel for completely resected non‐small cell lung cancer (NSCLC) (A). The primary endpoint of this study was tolerability, assessed by the completion rate of the planned four chemotherapy cycles. As a result, it was 74.3%, exceeding that reported for the
Koji Teramoto   +9 more
wiley   +1 more source

Rapid quantification of polysorbates in complex in-process formulation buffers using variable pathlength UV spectrometry with a slope-intercept strategy

open access: yesJournal of Pharmaceutical and Biomedical Analysis Open
We developed a rapid method using variable pathlength UV spectrometry combined with a slope-intercept strategy to quantify polysorbates in complex in-process formulation buffers for biologics manufacturing.
Guanglou Cheng   +5 more
doaj   +1 more source

DETERMINATION OF POLYSORBATES BY SPECTROPHOTOMETRY IN DRUGS BASED ON RECOMBINANT PROTEINS

open access: yesРазработка и регистрация лекарственных средств, 2019
Method of determination of polysorbate 20 and polysorbate 80 in recombinant protein drugs based on spectrophotometry has been designed. Isolation of polysorbate from solution is carried out by solid phase extraction followed by elution of polysorbate ...
A. D. Askretkov   +3 more
doaj  

Monoclonal Antibodies Aggregation during Administration to Patients and the Role of Pharmaceutical Excipients

open access: yesJournal of Food and Pharmaceutical Sciences
Monoclonal antibodies (mAbs) are powerful therapeutic agents known for their high specificity and effectiveness in treating complex diseases. Yet, one of their major challenges is their tendency to aggregate, which can reduce treatment efficacy and even ...
Deta Almira   +3 more
doaj   +1 more source

From Composition to Function: Defining Functional Equivalence in Plant‐Based Meat Analogs

open access: yes
Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Akila Srinivasagam Ramasamy Venkateswaran   +1 more
wiley   +1 more source

Defining Structure‐Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra‐Stable Biopharmaceuticals

open access: yesAdvanced Science
Biopharmaceuticals are the fastest‐growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation.
Alexander N. Prossnitz   +7 more
doaj   +1 more source

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