Results 81 to 90 of about 9,191 (255)

Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]

Journal of Excipients and Food Chemicals
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
doaj  

A brief account of nanoparticle contrast agents for photoacoustic imaging [PDF]

, 2013
Photoacoustic imaging (PAI) is a hybrid, nonionizing modality offering excellent spatial resolution, deep penetration, and high soft tissue contrast.
Kim, Benjamin, Lanza, Gregory M., Pan, Dipanjan, Wang, Lihong V.   +3 more
core   +1 more source

The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study

Phytotherapy Research, EarlyView.
In vitro and in vivo effects of PTSO in colorectal cancer preclinical models, highlighting antiproliferative, pro‐apoptotic, barrier‐enhancing, antitumor, prebiotic and immunomodulatory properties. Created using BioRender. ABSTRACT Allium‐derived organosulfur compounds offer significant health benefits.
María Jesús Rodríguez‐Sojo, Laura Hidalgo‐García, Jose Alberto Molina‐Tijeras, Laura López‐Escanez, Luckman Gbati, Teresa Vezza, Patricia Diez‐Echave, Antonio Jesús Ruiz‐Malagón, Jorge García‐García, Federico García, Alberto Baños, Lidia Gil‐Martínez, Rocío López‐Posadas, Markus F. Neurath, Julio Gálvez, María Elena Rodríguez‐Cabezas, Alba Rodríguez‐Nogales   +16 more
wiley   +1 more source

Boosting brackish water treatment via integration of mesoporous γ-Al2O3NPs with thin-film nanofiltration membranes

Scientific Reports, 2022
In this study, a simple method based on non-ionic surfactant polysorbates-80 was used to create mesoporous γ-Al2O3NPs. The properties of the prepared mesoporous alumina nanoparticles (Al2O3NPs) were verified using ATR-FTIR, XRD, SEM, TEM, DLS, and BET ...
Gamal K. Hassan, Mona Al-Shemy, Abeer M. Adel, Aly Al-Sayed   +3 more
doaj   +1 more source

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges [PDF]

, 2016
The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore ...
Al Shafiee, Maen, Kaialy, Waseem
core   +1 more source

Activating Paper Applying Gelatin, Starch and Chitosan Coatings Loaded With O/W Emulsions Encapsulating Rutin, Carvacrol and α‐Tocopherol

Packaging Technology and Science, EarlyView.
Emulsion type governed the microstructure and functionality of papers coated with biopolymers matrix loaded with hydrophobic bioactives encapsulated into O/W emulsions. Emulsified systems improved UV–Vis barrier and antioxidant activity, whereas gelatin coatings with conventional or Pickering emulsions provided the greatest mechanical reinforcement ...
Kamila de L. Santos, Ana Mônica Quinta Barbosa Bittante, Rodrigo Vinícius Lourenço, Júlio Cesar de Carvalho Balieiro, Paulo José do Amaral Sobral   +4 more
wiley   +1 more source

Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations” [PDF]

, 2013
The large number of drug candidates with poor dissolution characteristics seen in the past decade, has fostered interest in so-called "enabling formulations", i.e., formulations which shall make such drugs bio-available.
Brandl, Martin, Buckley, Stephen, Frank, Kerstin, Fricker, Gert   +3 more
core   +1 more source

Structural Profiling of Lipid Nanoparticles at Sub‐10 nm Resolution via AF4 Coupled Online to SAXS and SANS

Small Methods, EarlyView.
Dilution‐controlled AF4 coupled with SAXS and, for the first time, SANS enables high‐resolution characterization of non‐spherical lipid nanoparticles. Enhanced scattering contrast and D2O‐based measurements resolve particle features down to ∼5 nm and reveal shape distributions.
Eva Bittrich, Susanne Boye, Zanelle Van Niekerk, Zahn Stanvliet, Arthur Porfetye, Fátima Herranz‐Trillo, Hans Bolinsson, Stefaniya Gaydarova, Christo Tzachev, Anne Martel, Lars Nilsson, Ralf Schweins, Albena Lederer   +12 more
wiley   +1 more source

Electrospun Phospholipid Fibers as Micro-Encapsulation and Antioxidant Matrices [PDF]

, 2017
Electrospun phospholipid (asolectin) microfibers were investigated as antioxidants and encapsulation matrices for curcumin and vanillin. These phospholipid microfibers exhibited antioxidant properties which increased after the encapsulation of both ...
Baj, Vanessa, Beeren, Sophie R, Chronakis, Ioannis S., Mendes, Ana Carina Loureiro, Shekarforoush, Elhamalsadat   +4 more
core   +2 more sources

Gas Chromatographic Determination of 1,4-Dioxane in Polysorbate 60 and Polysorbate 80

Journal of AOAC INTERNATIONAL, 1979
Abstract A gas chromatographic method is presented for the quantitative determination of 1,4- dioxane in polysorbate 60 and polysorbate 80. Dioxane is isolated from the matrix by closedsystem vacuum distillation with water as the carrier solvent.
Thomas Fazio, Charles R Warner, Thomas J Birkel   +2 more
openaire   +1 more source