Clinical Pharmacology &Therapeutics, EarlyView.Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka +12 more
wiley +1 more source
Milk Chemical Composition of Dairy Cows Fed Rations Containing Protected Omega-3 Fatty Acids and Fermented Rice Bran [PDF]
, 2013 The research was conducted to investigate the effect of ration containing protected omega-3 and fermented rice bran on chemical composition of dairy milk. The research employed 10 female PFH dairy cows of 2-4 years old with body weight 300-375 kg.
Purnomo, S. H. (S) +1 more
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International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with brain volume reduction, glial cell loss, microbiome alterations, and dysregulated pro‐inflammatory mechanisms. However, the underlying cellular mechanisms remain inadequately elucidated, and interventions addressing these alterations are lacking.
A. C. Thelen +17 more
wiley +1 more source
Amino acid and fatty acid profiles in raw and cooked swamp buffalo meat (Bubalus bubalis)
Czech Journal of Food SciencesThe purpose of this study was to assess the amino acid and fatty acid profiles of swamp buffalo meat (Bubalus bubalis) obtained from a local market. The extractable free amino acids and free fatty acids of raw and cooked loin (Longissimus lumborum: LL ...
Thassawan Somchan +2 more
doaj +1 more source
Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates [PDF]
, 2007 Catherine J. Field +3 more
openalex +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder [PDF]
, 2013 M. Elizabeth Sublette +6 more
openalex +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source
Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure [PDF]
, 2017 No abstract ...
Freeman, Dilys J., Meyer, Barbara J.
core
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source