Results 181 to 190 of about 191,601 (231)

The hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis. [PDF]

Mol Metab
Scaricamazza S, Nesci V, Fenili G, Tiberi M, Percio A, Rosina M, Salvatori I, Riggio F, Candelise N, Pieroni L, Greco V, Chiurchiù V, Ferri A, Valle C.   +13 more
europepmc   +1 more source

Runtime Monitoring of Static Fairness Properties

Henzinger TA, Karimi M, Kueffner K, Mallik K.   +3 more
europepmc   +1 more source

Hypothalamic POMC neurons promote cannabinoid-induced feeding [PDF]

Nature, 2015
Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC neurons.
Luis Varela, Jae Geun Kim, Jung Dae Kim
exaly   +6 more sources

POMC Neurons: From Birth to Death [PDF]

Annual Review of Physiology, 2017
The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the
Chitoku Toda, Anna Santoro, Jung Dae Kim
exaly   +4 more sources

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POMC and Fibroblast Biology

Annals of the New York Academy of Sciences, 1999
ABSTRACT: We evidenced in vitro proopiomelanocortin (POMC) mRNA‐transcription in human dermal fibroblasts using Northern blot hybridization. Modulation of POMC gene expression by cytokines (transforming growth factor‐β, TGF‐β, and tumor necrosis factor‐α, TNF‐α) was investigated by incubating human normal fibroblasts with 1 and 10 ng/ml cytokines ...
T, Lotti, P, Teofoli, B, Bianchi, A, Mauviel   +3 more
openaire   +2 more sources

Implications of Proopiomelanocortin (POMC) Mutations in Humans: The POMC Deficiency Syndrome

Trends in Endocrinology & Metabolism, 2000
The recent discovery of the contribution of proopiomelanocortin (POMC)-derived peptides to the regulation of energy homeostasis and exocrine gland secretion in mice aroused new interest in the complex function of the endocrine POMC network. In addition, the first mutations in the gene encoding POMC have been identified in two patients affected by ...
H, Krude, A, Grüters
openaire   +2 more sources

POMC: The Physiological Power of Hormone Processing [PDF]

Physiological Reviews, 2018
Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and neuropeptides. In this review, we examine the variability in the individual peptides produced in different tissues and the impact of the simultaneous presence of their precursors or fragments.
Erika Harno, Thanuja Gali Ramamoorthy, Anne M White   +2 more
exaly   +3 more sources

Cladistic analysis of anuran POMC sequences

Peptides, 2002
Procedures for performing cladistic analyses can provide powerful tools for understanding the evolution of neuropeptide and polypeptide hormone coding genes. These analyses can be done on either amino acid data sets or nucleotide data sets and can utilize several different algorithms that are dependent on distinct sets of operating assumptions and ...
Jasem, Alrubaian, Phillip, Danielson, David, Walker, Robert M, Dores   +3 more
openaire   +2 more sources

Evaluating the radiation of the POMC gene in teleosts: characterization of American eel POMC

General and Comparative Endocrinology, 2003
A distinctive feature of the pituitary hormone precursor, proopiomelanocortin (POMC), is the presence of multiple melanocortin core sequences (HFRW), and one copy of the opioid, beta-endorphin. In the older lineages of ray-finned fish (i.e., orders Acipenseriformes and Semionotiformes), certain extant lobe-finned fish (Australian lungfish and African ...
Jasem, Alrubaian, Cristina, Sollars, Phillip B, Danielson, Robert M, Dores   +3 more
openaire   +2 more sources

PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake

American Journal of Physiology-Endocrinology and Metabolism, 2010
Both insulin and leptin signaling converge on phosphatidylinositol 3-OH kinase [PI( 3 )K]/3-phosphoinositide-dependent protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI( 3 )K-dependent manner.
Kristy, Iskandar, Yongheng, Cao, Yoshitake, Hayashi, Masanori, Nakata, Eisuke, Takano, Toshihiko, Yada, Changliang, Zhang, Wataru, Ogawa, Miyo, Oki, Streamson, Chua, Hiroshi, Itoh, Tetsuo, Noda, Masato, Kasuga, Jun, Nakae   +13 more
openaire   +2 more sources