Results 181 to 190 of about 189,310 (233)

Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability. [PDF]

Proc Natl Acad Sci U S A
López S, Elizondo-Vega R, Azócar V, Sepúlveda V, Opazo-Mellado V, Vásquez W, Sáez JC, Araneda RC, García-Robles MLÁ.   +8 more
europepmc   +1 more source

Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-derived Peptides in Murine Skin [PDF]

Journal of Histochemistry and Cytochemistry, 2000
In murine skin, after depilation-induced anagen, there was a differential spatial and temporal expression of pro-opiomelanocortin (POMC) mRNA, of the POMC-derived peptides β-endorphin, ACTH, β-MSH, and α-MSH, and of the prohormone convertases PC1 and ...
Joseph E Mazurkiewicz
exaly   +4 more sources

Functional heterogeneity of POMC neurons relies on mTORC1 signaling [PDF]

Cell Reports, 2021
Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions are poorly ...
Wilfrid Mazier, Luigi Bellocchio, Giles Yeo   +2 more
exaly   +3 more sources

Obesity, POMC, and POMC-processing Enzymes: Surprising Results From Animal Models. [PDF]

Endocrinology, 2021
Abstract Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides and peptide hormones that perform multiple functions, including regulation of body weight. In humans and some animals, these peptides include α– and β–melanocyte-stimulating hormone (MSH). In certain rodent species, no β-MSH is produced from POMC
Lloyd D Fricker, Iris Lindberg
exaly   +3 more sources

DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons

Cell Metabolism, 2017
Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined.
Chen Liu, Rosaria Meli, Hiromi Sesaki
exaly   +2 more sources

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Implications of Proopiomelanocortin (POMC) Mutations in Humans: The POMC Deficiency Syndrome

Trends in Endocrinology & Metabolism, 2000
The recent discovery of the contribution of proopiomelanocortin (POMC)-derived peptides to the regulation of energy homeostasis and exocrine gland secretion in mice aroused new interest in the complex function of the endocrine POMC network. In addition, the first mutations in the gene encoding POMC have been identified in two patients affected by ...
H, Krude, A, Grüters
openaire   +2 more sources