Results 201 to 210 of about 179,797 (233)

Effect of ethane dimethane sulphonate on proopiomelanocortin (POMC) mRNA and POMC-derived peptides in the rat testis

Molecular and Cellular Endocrinology, 1989
Recent studies have shown that both proopiomelanocortin (POMC)-derived peptides and a range of POMC gene transcripts are present in the testis. Previous immunocytochemical studies have reported immunoreactive (ir)-beta-endorphin (EP) and ir-ACTH to be localized in the Leydig cells, and ir-NacEP in spermatogonia and primary spermatocytes. In the present
H, Li, G P, Risbridger, J W, Funder, J A, Clements   +3 more
openaire   +2 more sources

PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake

American Journal of Physiology-Endocrinology and Metabolism, 2010
Both insulin and leptin signaling converge on phosphatidylinositol 3-OH kinase [PI( 3 )K]/3-phosphoinositide-dependent protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI( 3 )K-dependent manner.
Kristy, Iskandar, Yongheng, Cao, Yoshitake, Hayashi, Masanori, Nakata, Eisuke, Takano, Toshihiko, Yada, Changliang, Zhang, Wataru, Ogawa, Miyo, Oki, Streamson, Chua, Hiroshi, Itoh, Tetsuo, Noda, Masato, Kasuga, Jun, Nakae   +13 more
openaire   +2 more sources

POMC‐Derived Peptides and Their Biological Action

Annals of the New York Academy of Sciences, 1999
ABSTRACT:It has long been known that a large number of POMC‐related peptides are found in skin. In this introduction I describe the formation of POMC‐derived peptides in various tissues to indicate that processing is largely tissue‐dependent. I focus on the peptides from the N‐terminal fragment, such as γ‐MSH, ACTH and α‐MSH, and β‐lipopropin as well ...
openaire   +2 more sources

Mitochondrial regulation of obesity by POMC neurons

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Pro-opiomelanocortin (POMC) neurons, nestled in the hypothalamus, play a pivotal role in the intricate coordination of energy homeostasis and metabolic pathways. These neurons' mitochondria, often hailed as the cell's powerhouses, are crucial for maintaining cellular energy equilibrium and metabolic functionality.
Xing-Dan, Luo, Si, Tang, Xiang-Yun, Luo, Luosang, Quzhen, Ruo-Han, Xia, Xian-Wang, Wang   +5 more
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POMC Peptides in Adrenal Maintenance and Function

Endocrine Research, 2004
Adult mouse mutants homozygous for an engineered proopiomelanocortin (POMC) null allele lack morphologically distinct adrenal glands and circulating adrenal hormones (Yaswen et al. Nature Medicine 1999; 5:1066). To understand the basis for this adrenal defect, we compared the development of adrenal primordia in POMC null and littermate controls.
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IDENTIFICATION OF A RECEPTOR FOR N-POMC PEPTIDES

Endocrine Research, 2002
The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in rapid atrophy of the gland ...
openaire   +2 more sources

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Cell Metabolism, 2021
Alicia G Gómez-Valadés, Luis Varela, Sara Ramirez   +2 more
exaly  

POMC

2006
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Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use

Genetics in Medicine, 2023
Lauriane Le Collen, Benedicte Toussaint, Aurélie Dechaume   +2 more
exaly  

Implications of the Phenotype of POMC Deficiency for the Role of POMC‐Derived Peptides in Skin Physiology

Annals of the New York Academy of Sciences, 1999
H, Krude, D, Schnabel, W, Luck, A, Grüters   +3 more
openaire   +2 more sources