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POMC Peptides in Adrenal Maintenance and Function
Endocrine Research, 2004Adult mouse mutants homozygous for an engineered proopiomelanocortin (POMC) null allele lack morphologically distinct adrenal glands and circulating adrenal hormones (Yaswen et al. Nature Medicine 1999; 5:1066). To understand the basis for this adrenal defect, we compared the development of adrenal primordia in POMC null and littermate controls.
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IDENTIFICATION OF A RECEPTOR FOR N-POMC PEPTIDES
Endocrine Research, 2002The adrenal cortex is a dynamic organ in which the cells of the outer cortex continually divide. It is well known that this cellular proliferation is dependent on constant stimulation from peptides derived from the ACTH precursor proopiomelanocortin (POMC) since disruption of pituitary corticotroph function results in rapid atrophy of the gland ...
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