Results 191 to 200 of about 191,601 (231)
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Endocrinology, 1988
The effect of salt loading on POMC-derived peptide secretion, POMC mRNA levels, and POMC biosynthesis in the mouse pituitary gland was investigated. Plasma alpha MSH levels decreased to 56.9% of the control value after 2 days of salt loading. Concomitantly, POMC mRNA levels and POMC biosynthesis in the intermediate lobe decreased to 47.7% and 66.4% of ...
S, Elkabes, Y P, Loh
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The effect of salt loading on POMC-derived peptide secretion, POMC mRNA levels, and POMC biosynthesis in the mouse pituitary gland was investigated. Plasma alpha MSH levels decreased to 56.9% of the control value after 2 days of salt loading. Concomitantly, POMC mRNA levels and POMC biosynthesis in the intermediate lobe decreased to 47.7% and 66.4% of ...
S, Elkabes, Y P, Loh
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GLP1R agonists activate human POMC neurons
AbstractDrugs like Semaglutide (a.k.a. Ozempic/Wegovy) that activate the glucagon-like peptide-1 receptor (GLP1R) are a promising therapy for obesity and type 2 diabetes (T2D). Animal studies suggest that appetite-suppressing proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus are a likely target of these drugs, but the ...Simone Mazzaferro +12 more
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Infertility in POMC-deficient mice
PhysiologyThe pro-opiomelanocortin (POMC) gene is expressed in the hypothalamus and pituitary and its product is cleaved into several peptides including the melanocyte stimulating hormones (α, β, or γ-MSH), adrenocorticotropic hormone (ACTH), and beta-endorphin.
Andrew Geddes, Zoe Thompson
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POMC‐Derived Peptides and Their Biological Action
Annals of the New York Academy of Sciences, 1999ABSTRACT:It has long been known that a large number of POMC‐related peptides are found in skin. In this introduction I describe the formation of POMC‐derived peptides in various tissues to indicate that processing is largely tissue‐dependent. I focus on the peptides from the N‐terminal fragment, such as γ‐MSH, ACTH and α‐MSH, and β‐lipopropin as well ...
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Science's STKE, 2006
Proopiomelanocortin (POMC), which is expressed in several different tissues, undergoes posttranslational processing to yield various physiologically active peptide products. In the hypothalamus, POMC is a precursor to the melanocortins (α-MSH, β-MSH, and γ-MSH).
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Proopiomelanocortin (POMC), which is expressed in several different tissues, undergoes posttranslational processing to yield various physiologically active peptide products. In the hypothalamus, POMC is a precursor to the melanocortins (α-MSH, β-MSH, and γ-MSH).
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Mitochondrial regulation of obesity by POMC neurons
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseasePro-opiomelanocortin (POMC) neurons, nestled in the hypothalamus, play a pivotal role in the intricate coordination of energy homeostasis and metabolic pathways. These neurons' mitochondria, often hailed as the cell's powerhouses, are crucial for maintaining cellular energy equilibrium and metabolic functionality.
Xing-Dan, Luo +5 more
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Long-Term MC4R Agonist Treatment in POMC-Deficient Patients
New England Journal of Medicine, 2022Peter Kühnen
exaly