Results 191 to 200 of about 179,797 (233)
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
Cell Metabolism, 2017 Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined.
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Implications of Proopiomelanocortin (POMC) Mutations in Humans: The POMC Deficiency Syndrome
Trends in Endocrinology & Metabolism, 2000The recent discovery of the contribution of proopiomelanocortin (POMC)-derived peptides to the regulation of energy homeostasis and exocrine gland secretion in mice aroused new interest in the complex function of the endocrine POMC network. In addition, the first mutations in the gene encoding POMC have been identified in two patients affected by ...
H, Krude, A, Grüters
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Annals of the New York Academy of Sciences, 1999
ABSTRACT: We evidenced in vitro proopiomelanocortin (POMC) mRNA‐transcription in human dermal fibroblasts using Northern blot hybridization. Modulation of POMC gene expression by cytokines (transforming growth factor‐β, TGF‐β, and tumor necrosis factor‐α, TNF‐α) was investigated by incubating human normal fibroblasts with 1 and 10 ng/ml cytokines ...
T, Lotti +3 more
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ABSTRACT: We evidenced in vitro proopiomelanocortin (POMC) mRNA‐transcription in human dermal fibroblasts using Northern blot hybridization. Modulation of POMC gene expression by cytokines (transforming growth factor‐β, TGF‐β, and tumor necrosis factor‐α, TNF‐α) was investigated by incubating human normal fibroblasts with 1 and 10 ng/ml cytokines ...
T, Lotti +3 more
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POMC Neurons: From Birth to Death [PDF]
Annual Review of Physiology, 2017 The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the
Chitoku Toda +2 more
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Evaluating the radiation of the POMC gene in teleosts: characterization of American eel POMC
General and Comparative Endocrinology, 2003A distinctive feature of the pituitary hormone precursor, proopiomelanocortin (POMC), is the presence of multiple melanocortin core sequences (HFRW), and one copy of the opioid, beta-endorphin. In the older lineages of ray-finned fish (i.e., orders Acipenseriformes and Semionotiformes), certain extant lobe-finned fish (Australian lungfish and African ...
Jasem, Alrubaian +3 more
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Endocrinology, 1988
The effect of salt loading on POMC-derived peptide secretion, POMC mRNA levels, and POMC biosynthesis in the mouse pituitary gland was investigated. Plasma alpha MSH levels decreased to 56.9% of the control value after 2 days of salt loading. Concomitantly, POMC mRNA levels and POMC biosynthesis in the intermediate lobe decreased to 47.7% and 66.4% of ...
S, Elkabes, Y P, Loh
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The effect of salt loading on POMC-derived peptide secretion, POMC mRNA levels, and POMC biosynthesis in the mouse pituitary gland was investigated. Plasma alpha MSH levels decreased to 56.9% of the control value after 2 days of salt loading. Concomitantly, POMC mRNA levels and POMC biosynthesis in the intermediate lobe decreased to 47.7% and 66.4% of ...
S, Elkabes, Y P, Loh
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Cladistic analysis of anuran POMC sequences
Peptides, 2002Procedures for performing cladistic analyses can provide powerful tools for understanding the evolution of neuropeptide and polypeptide hormone coding genes. These analyses can be done on either amino acid data sets or nucleotide data sets and can utilize several different algorithms that are dependent on distinct sets of operating assumptions and ...
Jasem, Alrubaian +3 more
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Science's STKE, 2006
Proopiomelanocortin (POMC), which is expressed in several different tissues, undergoes posttranslational processing to yield various physiologically active peptide products. In the hypothalamus, POMC is a precursor to the melanocortins (α-MSH, β-MSH, and γ-MSH).
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Proopiomelanocortin (POMC), which is expressed in several different tissues, undergoes posttranslational processing to yield various physiologically active peptide products. In the hypothalamus, POMC is a precursor to the melanocortins (α-MSH, β-MSH, and γ-MSH).
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Prevalence of POMC R236G mutation in Pakistan
Obesity Research & Clinical Practice, 2016Obesity has become a great health issue and socioeconomic burden globally in the past few decades and has afflicted Pakistan in the same way. However, there is limited research on obesity genetics in Pakistan. Proopiomelanocortin (POMC) neurons bear leptin receptor and act as anorectic targets of leptin in the brain.
null Shabana, Shahida Hasnain
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Acta Histochemica, 2001
The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS ...
G, Keilhoff +7 more
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The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS ...
G, Keilhoff +7 more
openaire +2 more sources