Results 191 to 200 of about 189,310 (233)
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Annals of the New York Academy of Sciences, 1999
ABSTRACT: We evidenced in vitro proopiomelanocortin (POMC) mRNA‐transcription in human dermal fibroblasts using Northern blot hybridization. Modulation of POMC gene expression by cytokines (transforming growth factor‐β, TGF‐β, and tumor necrosis factor‐α, TNF‐α) was investigated by incubating human normal fibroblasts with 1 and 10 ng/ml cytokines ...
T, Lotti +3 more
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ABSTRACT: We evidenced in vitro proopiomelanocortin (POMC) mRNA‐transcription in human dermal fibroblasts using Northern blot hybridization. Modulation of POMC gene expression by cytokines (transforming growth factor‐β, TGF‐β, and tumor necrosis factor‐α, TNF‐α) was investigated by incubating human normal fibroblasts with 1 and 10 ng/ml cytokines ...
T, Lotti +3 more
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Evaluating the radiation of the POMC gene in teleosts: characterization of American eel POMC
General and Comparative Endocrinology, 2003A distinctive feature of the pituitary hormone precursor, proopiomelanocortin (POMC), is the presence of multiple melanocortin core sequences (HFRW), and one copy of the opioid, beta-endorphin. In the older lineages of ray-finned fish (i.e., orders Acipenseriformes and Semionotiformes), certain extant lobe-finned fish (Australian lungfish and African ...
Jasem, Alrubaian +3 more
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Endocrinology, 1988
The effect of salt loading on POMC-derived peptide secretion, POMC mRNA levels, and POMC biosynthesis in the mouse pituitary gland was investigated. Plasma alpha MSH levels decreased to 56.9% of the control value after 2 days of salt loading. Concomitantly, POMC mRNA levels and POMC biosynthesis in the intermediate lobe decreased to 47.7% and 66.4% of ...
S, Elkabes, Y P, Loh
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The effect of salt loading on POMC-derived peptide secretion, POMC mRNA levels, and POMC biosynthesis in the mouse pituitary gland was investigated. Plasma alpha MSH levels decreased to 56.9% of the control value after 2 days of salt loading. Concomitantly, POMC mRNA levels and POMC biosynthesis in the intermediate lobe decreased to 47.7% and 66.4% of ...
S, Elkabes, Y P, Loh
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Prevalence of POMC R236G mutation in Pakistan
Obesity Research & Clinical Practice, 2016Obesity has become a great health issue and socioeconomic burden globally in the past few decades and has afflicted Pakistan in the same way. However, there is limited research on obesity genetics in Pakistan. Proopiomelanocortin (POMC) neurons bear leptin receptor and act as anorectic targets of leptin in the brain.
null Shabana, Shahida Hasnain
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Cladistic analysis of anuran POMC sequences
Peptides, 2002Procedures for performing cladistic analyses can provide powerful tools for understanding the evolution of neuropeptide and polypeptide hormone coding genes. These analyses can be done on either amino acid data sets or nucleotide data sets and can utilize several different algorithms that are dependent on distinct sets of operating assumptions and ...
Jasem, Alrubaian +3 more
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Science's STKE, 2006
Proopiomelanocortin (POMC), which is expressed in several different tissues, undergoes posttranslational processing to yield various physiologically active peptide products. In the hypothalamus, POMC is a precursor to the melanocortins (α-MSH, β-MSH, and γ-MSH).
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Proopiomelanocortin (POMC), which is expressed in several different tissues, undergoes posttranslational processing to yield various physiologically active peptide products. In the hypothalamus, POMC is a precursor to the melanocortins (α-MSH, β-MSH, and γ-MSH).
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Acta Histochemica, 2001
The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS ...
G, Keilhoff +7 more
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The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS ...
G, Keilhoff +7 more
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Molecular and Cellular Endocrinology, 1989
Recent studies have shown that both proopiomelanocortin (POMC)-derived peptides and a range of POMC gene transcripts are present in the testis. Previous immunocytochemical studies have reported immunoreactive (ir)-beta-endorphin (EP) and ir-ACTH to be localized in the Leydig cells, and ir-NacEP in spermatogonia and primary spermatocytes. In the present
H, Li +3 more
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Recent studies have shown that both proopiomelanocortin (POMC)-derived peptides and a range of POMC gene transcripts are present in the testis. Previous immunocytochemical studies have reported immunoreactive (ir)-beta-endorphin (EP) and ir-ACTH to be localized in the Leydig cells, and ir-NacEP in spermatogonia and primary spermatocytes. In the present
H, Li +3 more
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POMC‐Derived Peptides and Their Biological Action
Annals of the New York Academy of Sciences, 1999ABSTRACT:It has long been known that a large number of POMC‐related peptides are found in skin. In this introduction I describe the formation of POMC‐derived peptides in various tissues to indicate that processing is largely tissue‐dependent. I focus on the peptides from the N‐terminal fragment, such as γ‐MSH, ACTH and α‐MSH, and β‐lipopropin as well ...
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Mitochondrial regulation of obesity by POMC neurons
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseasePro-opiomelanocortin (POMC) neurons, nestled in the hypothalamus, play a pivotal role in the intricate coordination of energy homeostasis and metabolic pathways. These neurons' mitochondria, often hailed as the cell's powerhouses, are crucial for maintaining cellular energy equilibrium and metabolic functionality.
Xing-Dan, Luo +5 more
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