Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique [PDF]
Advanced Pharmaceutical Bulletin, 2011 Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by ...
Parvin Zakeri-Milani +5 more
doaj +5 more sources
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles [PDF]
Acta Pharmaceutica Sinica B, 2019 Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash
Jinsong Tao, Shing Fung Chow, Ying Zheng
doaj +2 more sources
Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing [PDF]
Pharmaceutics, 2020 Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process.
Hui-Won Cho +3 more
doaj +2 more sources
Preclinical Bioavailability Assessment of a Poorly Water-Soluble Drug, HGR4113, Using a Stable Isotope Tracer [PDF]
Pharmaceutics, 2023 Drug solubility limits intravenous dosing for poorly water-soluble medicines, which misrepresents their bioavailability estimation. The current study explored a method using a stable isotope tracer to assess the bioavailability of drugs that are poorly ...
Eun Ji Ha +5 more
doaj +2 more sources
Surfactant Mediated Accelerated and Discriminatory In Vitro Drug Release Method for PLGA Nanoparticles of Poorly Water-Soluble Drug [PDF]
Pharmaceuticals, 2022 In vitro drug release testing is an important quality control tool for formulation development. However, the literature has evidence that poly-lactide-co-glycolide (PLGA)-based formulations show a slower in vitro drug release than a real in vivo drug ...
Ritu Gupta +3 more
doaj +2 more sources
Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability [PDF]
Molecules, 2015 The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery ...
Marko Krstić +3 more
doaj +2 more sources
Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug [PDF]
Scientia Pharmaceutica, 2016 The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent.
Suporn Charumanee +4 more
doaj +2 more sources
Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug [PDF]
Asian Journal of Pharmaceutical Sciences, 2019 The purpose of the present study was to investigate the interaction of Cinnarizine (CIN) with Hydroxypropyl-β-Cyclodextrin (HPβCD) in the presence of Hydroxy Acids (HA).
Mayank Patel, Rajashree Hirlekar
doaj +2 more sources
Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs
Frontiers in Drug Delivery, 2023 Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy.
Popat Mohite +4 more
doaj +1 more source
Pharmaceuticals, 2022 This study aimed to construct a pH-responsive nanocrystalline hydrogel drug delivery system for topical delivery of insoluble drugs based on the self-assembly behavior of carboxymethyl chitosan (CMC) and oxidized hyaluronic acid (OHA).
Xiaohan Tang +3 more
doaj +1 more source