Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug. [PDF]
Polymers (Basel), 2022 In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs.
Liu Y, Chen X, Liu Y, Gao Y, Liu P.
europepmc +2 more sources
Pharmaceutics, 2019 Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water ...
Thao T. D. Tran, Phuong H. L. Tran
doaj +2 more sources
Solubilization techniques used for poorly water-soluble drugs
Acta Pharmaceutica Sinica BAbout 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
Bing Xie +4 more
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Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point. [PDF]
RSC Adv, 2019 The aim of the study was to develop an amorphous solid dispersion of a poorly water-soluble drug with high melting point by ball milling and hot melt extrusion as a co-processing method.
Fan W, Zhu W, Zhang X, Xu Y, Di L.
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Solubility Enhancement of Poorly Water Soluble Drug Aceclofenac
Indian Journal of Pharmacy and Pharmacology, 2016 Solid dispersion was aim for increasing solubility and bioavailability of poorly aqueous soluble drug aceclofenac (ACE). Solid dispersion of drug aceclofenac (NSAID) was prepared by using different polymers i.e. Polaxomer 188, PVP k30, PEG 6000, in different ratios 1:1, 1:2, 1:3, by different methods of solid dispersion preparation i.e.
Girish C. Soni, PD Chaudhary, PK Sharma
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Impact of Superdisintegrants and Film Thickness on Disintegration Time of Strip Films Loaded With Poorly Water-Soluble Drug Microparticles. [PDF]
J Pharm Sci, 2018 Although strip films are a promising platform for delivery of poorly water-soluble drug particles via slurry casting, the effect of critical material attributes, for example, superdisintegrants (SDIs) on critical quality attributes, including film ...
Zhang L +6 more
europepmc +2 more sources
Drug delivery strategies for poorly water-soluble drugs [PDF]
Expert Opinion on Drug Delivery, 2007 The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or
Alfred, Fahr, Xiangli, Liu
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Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting. [PDF]
Eur J Pharm Sci, 2018 Zhang L, Alfano J, Race D, Davé RN.
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Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs
Frontiers in Drug Delivery, 2023 Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy.
Popat Mohite +4 more
doaj +1 more source
Advanced Drug Delivery Reviews, 2022 Selecting the appropriate formulation and solubility-enabling technology for poorly water soluble drugs is an essential element in the development of formulations for paediatric patients. Different methodologies and structured strategies are available to
S. Salunke +7 more
semanticscholar +1 more source