Results 21 to 30 of about 198,472 (338)

Effects of Polymers on the Drug Solubility and Dissolution Enhancement of Poorly Water-Soluble Rivaroxaban

International Journal of Molecular Sciences, 2022
The purpose of this study was to investigate the efficacy of hydrophilic polymers in a solid dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB), a poorly soluble drug.
Min-Jong Choi, Mi Ran Woo, Han‐Gon Choi, S. Jin   +3 more
semanticscholar   +1 more source

Recent Technologies for Amorphization of Poorly Water-Soluble Drugs [PDF]

Pharmaceutics, 2021
Amorphization technology has been the subject of continuous attention in the pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs. Being in a high energy state, amorphous formulations generally display significantly increased apparent solubility as compared to their crystalline counterparts, which may allow them ...
Dohyun Kim, Youngwoo Kim, Yee-Yee Tin, Mya-Thet-Paing Soe, Byounghyen Ko, Sunjae Park, Jaehwi Lee   +6 more
openaire   +3 more sources

Development of a Self-Assembled Hydrogels Based on Carboxymethyl Chitosan and Oxidized Hyaluronic Acid Containing Tanshinone Extract Nanocrystals for Enhanced Dissolution and Acne Treatment

Pharmaceuticals, 2022
This study aimed to construct a pH-responsive nanocrystalline hydrogel drug delivery system for topical delivery of insoluble drugs based on the self-assembly behavior of carboxymethyl chitosan (CMC) and oxidized hyaluronic acid (OHA).
Xiaohan Tang, Yan Liu, Hailong Yuan, Rong Gao   +3 more
doaj   +1 more source

Use of Polyvinyl Alcohol as a Solubility-Enhancing Polymer for Poorly Water Soluble Drug Delivery (Part 1). [PDF]

AAPS PharmSciTech, 2016
Brough C, Miller DA, Keen JM, Kucera SA, Lubda D, Williams RO.   +5 more
europepmc   +2 more sources

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Formulation and optimization of drug-loaded mesoporous silica nanoparticle-based tablets to improve the dissolution rate of the poorly water-soluble drug silymarin.

European Journal of Pharmaceutical Sciences, 2020
Porous carriers have been put forward as a promising alternative for stabilizing the amorphous state of loaded drugs, and thus significantly improving the dissolution rate of poorly soluble compounds.
A. Ibrahim, J. Smått, N. Govardhanam, H. Ibrahim, Hatem R. Ismael, M. Afouna, A. Samy, J. Rosenholm   +7 more
semanticscholar   +1 more source

Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug. [PDF]

Int J Nanomedicine, 2016
Background Self-nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this study was to investigate the factor that can influence the design of successful ...
Mohsin K, Alamri R, Ahmad A, Raish M, Alanazi FK, Hussain MD.   +5 more
europepmc   +2 more sources

Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: I. Impact of plasticizer on film properties and dissolution. [PDF]

Eur J Pharm Sci, 2016
Krull SM, Patel HV, Li M, Bilgili E, Davé RN.   +4 more
europepmc   +2 more sources

Curcumin-loaded zeolite as anticancer drug carrier: Effect of curcumin adsorption on zeolite structure [PDF]

, 2020
In this work we used a combination of different techniques to investigate the adsorption properties of curcumin by zeolite type A for potential use as an anticancer drug carrier.
Ahali Abadeh, Z., Ballirano, P., Santonicola, M. G., Saviano, G.   +3 more
core   +1 more source

Development of pectin nanoparticles through mechanical homogenization for dissolution enhancement of itraconazole

Asian Journal of Pharmaceutical Sciences, 2016
A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared by a mechanical homogenization using pectin as emulsifier.
Kanokporn Burapapadh, Hirofumi Takeuchi, Pornsak Sriamornsak   +2 more
doaj   +1 more source