Results 31 to 40 of about 198,472 (338)
The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes. [PDF]
, 2015 A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use.
Chen, R +5 more
core +2 more sources
Pharmaceutics, 2018 Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang +3 more
doaj +1 more source
Insoluble drug delivery strategies: review of recent advances and business prospects
Acta Pharmaceutica Sinica B, 2015 The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
Sandeep Kalepu, Vijaykumar Nekkanti
doaj +1 more source
British Journal of Pharmacy, 2023 Forming amorphous solid dispersions (ASDs) is one method for improving the solubility and subsequent absorption of poorly-water soluble drugs. An ASD is a matrix of a poorly water-soluble compound with a hydrophilic polymer carrier, which stabilises ...
Elen Roberts +8 more
doaj +1 more source
Molecules, 2021 Some medicines are poorly soluble in water. For tube feeding and parenteral administration, liquid formulations are required. The discovery of natural deep eutectic solvents (NADES) opened the way to potential applications for liquid drug formulations ...
Natali Rianika Mustafa +4 more
doaj +1 more source
The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]
, 2014 The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi +8 more
core +1 more source
Nanosuspension: An approach to enhance solubility of drugs
Journal of Advanced Pharmaceutical Technology & Research, 2011 One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media ...
Vishal R Patel, Y K Agrawal
doaj +1 more source
Preparation of ethylcellulose/methylcellulose blends by supercritical antisolvent precipitation [PDF]
, 2006 The supercritical antisolvent (SAS) techniquewas used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier.
Cardoso, M. Margarida +4 more
core +1 more source
Journal of Pharmacy and Bioallied Sciences, 2012 Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity.
A Lodha +6 more
doaj +1 more source
Journal of Pharmacy and Science, 2019 A number of drugs that are currently on the market, as well as new candidates for drugs, are poorly water soluble. Because of this, a need exists to develop drug formulations that will permit the expanded use of such drugs. The use of liposomes and lipid
Mitsue Hibino +6 more
semanticscholar +1 more source