Results 41 to 50 of about 147,210 (303)
Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2020 Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid ...
Thao T. D. Tran, Phuong H. L. Tran
openaire +3 more sources
Molecules, 2016 The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative ...
Kyeong-Ok Choi +3 more
doaj +1 more source
Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]
, 2014 The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto +4 more
core +1 more source
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Vorinostat is a histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) with anticancer properties. However, it is plagued by low water solubility, low permeability (BCS class IV drug), and suboptimal pharmacokinetics. The purpose
Ashok Kumar Janakiraman +4 more
doaj +1 more source
Journal of Pharmacy and Bioallied Sciences, 2012 The aim of the present work is to formulate and evaluate in situ oral topical gels of poorly water soluble drug Bifonazole based on temperature induced systems for the treatment of oral candidiasis.
Dimendra Patel +4 more
doaj +1 more source
Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
Journal of Pharmacy and Bioallied Sciences, 2012 The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process.
Divyesh Thakar +2 more
doaj +1 more source
Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]
, 2015 The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco +4 more
core +1 more source
Asian Journal of Pharmaceutical Sciences, 2014 Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.
Prakash Khadka +8 more
doaj +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2010 In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents.
R K Maheshwari, Shruti Moondra
doaj +2 more sources
A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution
Asian Journal of Pharmaceutical Sciences, 2015 To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated.
Pornsak Sriamornsak +4 more
doaj +1 more source