The enhancement of the aqueous solubility of ritonavir via formulation of a drug-phospholipid complex [PDF]
, 2015 Objective: To evaluate the enhancement of aqueous solubility of a poorly water soluble drug ritonavir by forming its complex with a phospholipid (Phospholipon®90H)
Bernardez, M. +6 more
core +1 more source
Solid crystal suspension of Efavirenz using hot melt extrusion: exploring the role of crystalline polyols in improving solubility and dissolution rate [PDF]
, 2017 The poor aqueous solubility of drugs has emerged as a major issue for pharmaceutical scientists from many decades. The current study explores the manufacture and development of a thermodynamically stabilized solid crystal suspension (SCS) of poorly water
Amin, Purnima D +3 more
core +1 more source
Symurban Nanocrystals for Advanced Anti-Pollution Skincare [PDF]
, 2020 Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis, are worsened in their clinical picture when the skin is regularly exposed to an increased air pollution level, e.g., particulate matter.
Köpke, Daniel, Pyo, Sung Min
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase [PDF]
Pharmaciana, 2017 Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability.
Sani Ega Priani +2 more
doaj +1 more source
Alexandria Engineering Journal, 2022 The solubility of the poorly soluble drug raloxifene hydrochloride (3) in binary {dimethyl sulfoxide (DMSO) (1) + water (2)} mixtures have been recorded at several temperatures under atmospheric pressure.
Mohammad Alyamani +5 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique
Journal of Pharmacy and Bioallied Sciences, 2012 The present study was aimed to increase the solubility of the poorly water soluble drug benfotiamine using hydrophilic polymers (PVP K-30 and HPMC E4). Solid dispersions were prepared by kneading method.
S M Patel, R P Patel, B G Prajapati
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Study of dissolution rate enhancement of poorly water soluble drug [PDF]
, 2008 Aim of this work is the preparation of spray-dried microspheres as drug delivery systems for Rokitamycin (RK), using chitosan (C) and its salt, chitosan glutamate (CG) to improve the dissolution rate of the drug.
Gavini, Elisabetta +3 more
core