Results 61 to 70 of about 198,472 (338)

Dissolution enhancement of gliclazide using pH change approach in presence of twelve stabilizers with various physico-chemical properties [PDF]

, 2009
Purpose. The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability.
Mostafavi, Seyed Abolfazl, Nokhodchi, Ali, Talari, Roya, Varshosaz, Jaleh   +3 more
core   +2 more sources

Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid.

European journal of pharmaceutics and biopharmaceutics, 2016
Poor transdermal penetration of active pharmaceutical ingredients (APIs) impairs both bioavailability and therapeutic benefits and is a major challenge in the development of transdermal drug delivery systems.
Y. Miwa, H. Hamamoto, T. Ishida
semanticscholar   +1 more source

Formulation of thermoresponsive and buccal adhesive in situ gel for treatment of oral thrush containing poorly water soluble drug bifonazole

Journal of Pharmacy and Bioallied Sciences, 2012
The aim of the present work is to formulate and evaluate in situ oral topical gels of poorly water soluble drug Bifonazole based on temperature induced systems for the treatment of oral candidiasis.
Dimendra Patel, Dipti Patel, Jatin Prajapati, Umang Patel, Vijay Patel   +4 more
doaj   +1 more source

Solid crystal suspension of Efavirenz using hot melt extrusion: exploring the role of crystalline polyols in improving solubility and dissolution rate [PDF]

, 2017
The poor aqueous solubility of drugs has emerged as a major issue for pharmaceutical scientists from many decades. The current study explores the manufacture and development of a thermodynamically stabilized solid crystal suspension (SCS) of poorly water
Amin, Purnima D, Fule, Ritesh A, Maniruzzaman, Mohammed, Pawar, Jaywant N   +3 more
core   +1 more source

Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach

Journal of Pharmacy and Bioallied Sciences, 2012
The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process.
Divyesh Thakar, Praful Bharadia, Vikram Pandya   +2 more
doaj   +1 more source

Development and characterization of mixed niosomes for oral delivery using candesartan cilexetil as a model poorly water-soluble drug. [PDF]

AAPS PharmSciTech, 2015
Sezgin-Bayindir Z, Antep MN, Yuksel N.
europepmc   +2 more sources

Two-Stage Crystallizer Design for High Loading of Poorly Water-Soluble Pharmaceuticals in Porous Silica Matrices [PDF]

, 2017
While porous silica supports have been previously studied as carriers for nanocrystalline forms of poorly water-soluble active pharmaceutical ingredients (APIs), increasing the loading of API in these matrices is of great importance if these carriers are
Dwyer, Leia Mary, Kulkarni, Samir, Myerson, Allan S., Ruelas, Luzdary T.   +3 more
core   +2 more sources

Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Poorly Water-Soluble Talinolol: Preparation, in vitro and in vivo Assessment

Frontiers in Pharmacology, 2019
Objective The aim of this study was to investigate the in vitro and in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of talinolol (TAL), a poorly water-soluble drug.
Mohsin Kazi, Mohammed Al-Swairi, Ajaz Ahmad, Mohammad Raish, F. Alanazi, M. Badran, A. A. Khan, A. Alanazi, M. D. Hussain   +8 more
semanticscholar   +1 more source

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Asian Journal of Pharmaceutical Sciences, 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.
Prakash Khadka, Jieun Ro, Hyeongmin Kim, Iksoo Kim, Jeong Tae Kim, Hyunil Kim, Jae Min Cho, Gyiae Yun, Jaehwi Lee   +8 more
doaj   +1 more source

A novel method for quantitative determination of aceclofenac in bulk drug and tablets using sodium salicylate as a hydrotropic solubilizing agent

Journal of Advanced Pharmaceutical Technology & Research, 2010
In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents.
R K Maheshwari, Shruti Moondra
doaj   +2 more sources