Results 61 to 70 of about 147,210 (303)

Solubilization of Poorly Water-soluble Drugs with Amphiphilic Phospholipid Polymers

YAKUGAKU ZASSHI, 2023
Most drug candidates developed in recent years are poorly water-soluble, which is a key challenge in pharmaceutical science. Various solubilization methods have been investigated thus far, most of which require solubilizers that provide a local hydrophobic environment wherein a drug can dissolve or induce interactions with drug molecules.
Kensuke, Yoshie, Kazuhiko, Ishihara
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]

, 2013
In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Klein, Sandra, Taupitz, Thomas
core  

Controlled release from zein matrices: Interplay of drug hydrophobicity and pH [PDF]

, 2015
Purpose: In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet the range of drugs for which zein has been studied remains small.
A Katchalsky, AL Sarode, D Xiao, DMR Georget, Erik van der Linden, FA Momany, GW Selling, H Chiue, H Kortejärvi, Jacob Bouman, JW Lawton, M Fujiwara, M Peleg, N Minagawa, NA Peppas, P Argos, P Hurtado-López, Paul Venema, Peter Belton, PL Ritger, PS Belton, Q Jiang, R Paliwal, R Shukla, RA Granberg, Renko de Vries, S Grund, S Podaralla, S Thakral, Sheng Qi, W Huang, X Liu, YH Yong, YK Oh, YK Oh   +34 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Preparation And Evaluation Of Fenofibrate-Gelucire 44/14 Solid Dispersions [PDF]

, 2007
Potensi formulasi berasaskan sebaran pepejal menggunapakai Gelucire 44/14 sebagai pembawa untuk meningkatkan pelarutan serta biokeperolehan oral fenofibrat, sejenis drug yang tak mudah larut, telah disiasat.
Al-Dhalli, Samer
core   +1 more source

Two-Stage Crystallizer Design for High Loading of Poorly Water-Soluble Pharmaceuticals in Porous Silica Matrices [PDF]

, 2017
While porous silica supports have been previously studied as carriers for nanocrystalline forms of poorly water-soluble active pharmaceutical ingredients (APIs), increasing the loading of API in these matrices is of great importance if these carriers are
Dwyer, Leia Mary, Kulkarni, Samir, Myerson, Allan S., Ruelas, Luzdary T.   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles [PDF]

, 2017
Unimolecular branched polymer nanoparticles are formed in methanol via a simple thermal annealing process, which can be used to produce aqueous drug nanoparticle suspensions.
He, Tao, Jackson, Alexander W, Liu, Jian-Hua, Wais, Ulrike, Wang, Yan-Hong, Xiang, Yu, Zhang, Haifei, Zuo, Yan-Ming   +7 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source