Results 71 to 80 of about 147,210 (303)

Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs

Pharmaceutics, 2019
Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water ...
Thao T. D. Tran, Phuong H. L. Tran
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs

Acta Pharmaceutica Sinica B, 2014
Water-insoluble materials containing amorphous solid dispersions (ASD) are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs.
Dajun D. Sun, Ping I. Lee
doaj   +1 more source

Soluplus solutions as thermothickening materials for topical drug delivery. [PDF]

, 2019
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed.
Abou Shamat, Mohamad, Cook, Michael
core   +2 more sources

Improved dissolution of Kaempferia parviflora extract for oral administration by preparing solid dispersion via solvent evaporation

Asian Journal of Pharmaceutical Sciences, 2017
Kaempferia parviflora, a plant in the family Zingiberaceae, has been used in Thai traditional medicines for treating hypertension and promoting longevity with good health and well-being.
Yotsanan Weerapol, Sukannika Tubtimsri, Chaweewan Jansakul, Pornsak Sriamornsak   +3 more
doaj   +1 more source

Solubility Enhancement of Poorly Water-Soluble Drugs

International Journal of Advanced Research in Science, Communication and Technology
This article provides an overview of nanocrystals as a potentially valuable technology for enhancing the solubility of water-insoluble pharmaceuticals. Nanocrystals increase surface area by reducing particle size, hence improving bioavailability and solubility.
null Mr. Sufiyan Ahemad Abdul Mukthar, null Mr. Vishal Singh Solanki   +1 more
openaire   +1 more source

Advancing Electronic Application of Coordination Solids: Enhancing Electron Transport and Device Integration via Surface‐Mounted MOFs (SURMOFs)

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of coordination solids, enabled by the surface‐mounted metal‐organic framework (SURMOF) platform, is on the cusp of generating the organic counterpart of the epitaxy of inorganics. The programmable and sequential SURMOF protocol, optimized by machine learning (ML), is suited for accessing high‐quality thin films of ...
Zhengtao Xu, Christof Wöll, Stefan Bräse   +2 more
wiley   +1 more source

Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization

Asian Journal of Pharmaceutical Sciences, 2015
The objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties.
Pornsak Sriamornsak, Kanokporn Burapapadh   +1 more
doaj   +1 more source

Solubilization techniques used for poorly water-soluble drugs

Acta Pharmaceutica Sinica B
About 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
Bing Xie, Yaping Liu, Xiaotong Li, Pei Yang, Wei He   +4 more
openaire   +2 more sources

Light‐Controlled Reversible Coassembly of Hybrid Functional Nanostructures

Advanced Functional Materials, EarlyView.
Light‐responsive hybrid nanostructures are formed by coassembling azobenzene‐ and PAH‐functionalized nanoparticles through reversible an tunable π interactions. The system enables tunable coupling between distinct components such as gold and magnetite or carbon nanotubes, producing switchable optical and magnetic properties under light and magnetic ...
Michal Sawczyk, Yanxiao Han, Soumyo Sen, Bartosz Smereczyński, Petr Král, Michał M. Wójcik   +5 more
wiley   +1 more source