Recent Technologies for Amorphization of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2021 Amorphization technology has been the subject of continuous attention in the pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs. Being in a high energy state, amorphous formulations generally display significantly
Dohyun Kim +6 more
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Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs [PDF]
Pharmaceuticals, 2022 The processes of solubilization and controlled release of drugs that are poorly soluble in water are highly relevant in drug preformulation studies in pharmaceutical development [...]
M. A. Peña
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Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2020 Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions.
Thao T. D. Tran, Phuong H. L. Tran
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Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs [PDF]
Molecules, 2015 Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery.
Matthew McKenzie +5 more
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Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs [PDF]
Frontiers in Drug Delivery, 2023 Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy.
Popat Mohite +4 more
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Novel cationic cellulose beads for oral delivery of poorly water-soluble drugs [PDF]
International Journal of Pharmaceutics: X, 2023 Cellulose beads emerge as carriers for poorly water-soluble drugs due to their eco-friendly raw materials and favorable porous structure. However, drug dissolution may be limited by their poor swelling ability and the presence of closed pores caused by ...
Fan Xie +3 more
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Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies [PDF]
Pharmaceutics, 2022 The poor bioavailability of many newly developed active pharmaceutical ingredients (APIs) poses a major challenge in formulation development. To overcome this issue, strategies such as the preparation of amorphous solid dispersions (ASDs), and the ...
Denise Steiner +2 more
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Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs [PDF]
Molecules, 2022 At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions,
Arvind Sharma +10 more
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Solubilization techniques used for poorly water-soluble drugs. [PDF]
Acta Pharm Sin BAbout 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
Xie B, Liu Y, Li X, Yang P, He W.
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In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging [PDF]
Acta Pharmaceutica Sinica B, 2021 In vitro‒in vivo correlation (IVIVC) of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients. Nevertheless, in vivo dissolution profiles have never been accurately portrayed. The
Yinqian Yang +9 more
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