Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs [PDF]
Asian Journal of Pharmaceutical SciencesWhile spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce
Jung Suk Kim +12 more
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Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2018 Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang +3 more
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Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium [PDF]
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS [PDF]
INDONESIAN JOURNAL OF PHARMACY, 2014 Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate.
Gohil, Tushar
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Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges [PDF]
Pharmaceutics, 2018 Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs.
Anagha Bhakay +3 more
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Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs [PDF]
Pharmaceutics, 2019 Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic ...
Phuong Tran +5 more
doaj +2 more sources
Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs [PDF]
Pharmaceutics, 2019 Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water ...
Thao T. D. Tran, Phuong H. L. Tran
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Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs [PDF]
Saudi Pharmaceutical Journal, 2017 The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties.
A.R. Fernandes +7 more
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Drug delivery strategies for poorly water-soluble drugs [PDF]
Expert Opinion on Drug Delivery, 2007 The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or
Alfred, Fahr, Xiangli, Liu
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Phytomedicine Plus, 2021 Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani +6 more
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