Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals, 2023 The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev +5 more
doaj +1 more source
Co-Amorphous System: A promising Strategy for Delivering Poorly Water - Soluble Drugs
Iraqi Journal of Pharmaceutical Sciences, 2020 Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability. Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy
Eman S. Aldahhan, Ameera A. Radhi
doaj +1 more source
Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs
Asian Journal of Pharmaceutical Sciences, 2015 Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness ...
Varaporn Buraphacheep Junyaprasert +1 more
doaj +1 more source
The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes. [PDF]
, 2015 A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use.
Chen, R +5 more
core +2 more sources
Automation potential of a new, rapid, microscopy based method for screening drug-polymer solubility [PDF]
, 2020 For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches.
Alhijjaj, Muqdad +4 more
core +1 more source
Anticancer activity of rutin and its combination with ionic liquids on renal cells [PDF]
, 2020 The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC.
Araújo, Maria Eduarda Machado +6 more
core +1 more source
The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]
, 2014 The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi +8 more
core +1 more source
Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]
, 2019 Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair +57 more
core +2 more sources
Dissolution enhancement of gliclazide using pH change approach in presence of twelve stabilizers with various physico-chemical properties [PDF]
, 2009 Purpose. The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability.
Mostafavi, Seyed Abolfazl +3 more
core +2 more sources
Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [PDF]
, 2019 Despite the fact that solid dispersions are gaining momentum, the number of polymers that have been used as a carrier during the past 50 years is rather limited.
Boel, Eline +5 more
core +1 more source