Results 31 to 40 of about 121,997 (290)

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto, Castro, Silvina Gabriela, González Vidal, Noelia Luján, Palma, Santiago Daniel, Sanchez Bruni, Sergio Fabian   +4 more
core   +1 more source

Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin

Pharmaceutics, 2023
The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility issues.
María Elena Gamboa-Arancibia, Nelson Caro, Alexander Gamboa, Javier Octavio Morales, Jorge Enrique González Casanova, Diana Marcela Rojas Gómez, Sebastián Miranda-Rojas   +6 more
doaj   +1 more source

Controlled release from zein matrices: Interplay of drug hydrophobicity and pH [PDF]

, 2015
Purpose: In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet the range of drugs for which zein has been studied remains small.
A Katchalsky, AL Sarode, D Xiao, DMR Georget, Erik van der Linden, FA Momany, GW Selling, H Chiue, H Kortejärvi, Jacob Bouman, JW Lawton, M Fujiwara, M Peleg, N Minagawa, NA Peppas, P Argos, P Hurtado-López, Paul Venema, Peter Belton, PL Ritger, PS Belton, Q Jiang, R Paliwal, R Shukla, RA Granberg, Renko de Vries, S Grund, S Podaralla, S Thakral, Sheng Qi, W Huang, X Liu, YH Yong, YK Oh, YK Oh   +34 more
core   +2 more sources

Solubility Enhancement of Poorly Water Soluble Drug

, 2023
The Biopharmaceutical Classification System includes solubility as one of its core criteria, and dissolution rate is the most crucial variable affecting a drug's bioavailability. A weakly water-soluble medication is defined as a substance with a solubility of less than 1 part per 10,000 parts of water.
Madkaikar, S.A., Shukla, U.D.
openaire   +1 more source

Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability

Pharmaceutics, 2023
The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman, Eli Lailasari, Neng Vera Nurani, Ellen Nathania Yunita, Gracia Anastasya, Rizqa Nurul Aulia, Ira Novianty Lestari, Laila Subra, Diah Lia Aulifa   +8 more
doaj   +1 more source

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source

Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]

, 2020
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham, Chen, Xing, Nikolakakis, Ioannis, Partheniadis, Ioannis   +3 more
core   +1 more source

Evaluation of Poorly Soluble Drugs’ Dissolution Rate by Laser Scattering in Different Water Isotopologues

Molecules, 2021
The most important task in the design of dosage forms is to modify the pharmaceutical substances structure in order to increase solubilization, targeted delivery, controlled rate of drug administration, and its bioavailability.
Elena V. Uspenskaya, Tatiana V. Pleteneva, Ilaha V. Kazimova, Anton V. Syroeshkin   +3 more
doaj   +1 more source

Antisolvent Crystallization of Poorly Water Soluble Drugs

International Journal of Chemical Engineering and Applications, 2013
The enhancement in bioavailability of the drugs is one of the most important concerning aspects of the pharmaceutical industries. Preparation of nanoparticles or microparticles of these drugs is the newest formulation strategies. The size and morphology of a drug are affecting several essential pharmaceutical properties.
Abhijit A. Lonare, Sanjaykumar R. Patel
openaire   +1 more source

Insoluble drug delivery strategies: review of recent advances and business prospects

Acta Pharmaceutica Sinica B, 2015
The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
Sandeep Kalepu, Vijaykumar Nekkanti
doaj   +1 more source