Results 111 to 120 of about 1,563,037 (290)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Unlocking the secret life of blue mussels: Exploring connectivity in the Skagerrak through biophysical modeling and population genomics

Evolutionary Applications
Knowledge of functional dispersal barriers in the marine environment can be used to inform a wide variety of management actions, such as marine spatial planning, restoration efforts, fisheries regulations, and invasive species management.
Malin Gustafsson, Åsa Strand, Ane T. Laugen, Jon Albretsen, Carl André, Göran Broström, Per Erik Jorde, Halvor Knutsen, Olga Ortega‐Martinez, Marte Sodeland, Malin Waern, Anna‐Lisa Wrange, Pierre De Wit   +12 more
doaj   +1 more source

Mosaic Structure of the Human Immunodeficiency Virus Type 1 Genome Infecting Lymphoid Cells and the Brain: Evidence for Frequent In Vivo Recombination Events in the Evolution of Regional Populations [PDF]

, 1999
Andrew Conway Morris, Matthew D. Marsden, K. Halcrow, E S Hughes, Ray P. Brettle, Jeanne E. Bell, Peter Simmonds   +6 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Moscow Population Before and After the COVID-19 Pandemic

Здоровье мегаполиса
Background. Moscow managed to overcome the challenges of the COVID-19 pandemic by increasing the efforts of the healthcare system and maintaining the birth rate. As a result, the population growth in Moscow remained steady.
A. A. Savina, E. V. Zemlyanova
doaj   +1 more source

Genealogical structuring of a population.

Collegium antropologicum, 2001
The study observed population of 484 generation restrictive genealogies collected in four Croatian regions during 1970/71 within "The study of fat and carbohydrate metabolism indicators correlated with the occurrence of diabetes in animal fat and oil consuming population groups".
Kujundžić Tiljak, M., Kern, J., Ivanković, D., Tiljak, H., Vuletić, S.   +4 more
openaire   +4 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Hardy–Weinberg Equilibrium Filtering in Population Genomics: Empirical Review and Decision Framework for Improved Practice

Ecology and Evolution
Hardy–Weinberg equilibrium (HWE) filtering remains widely used in population genomics, but its application remains inconsistent, often lacking detailed justification, and not always aligned with biological context.
Yu‐Hsun Hsu
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source