Results 151 to 160 of about 148,131 (169)

Human Fibroblasts Are Permissive for Porcine Cytomegalovirus In Vitro

Transplantation, 2008
Xenotransplantation with pig organs is being considered to alleviate donor organ shortages; however, the risk of introducing porcine viruses into humans is heightened in this setting. The goal of this study was to determine the infectious potential of porcine cytomegalovirus (PCMV), a xenozoonotic virus of interest, in human fibroblasts in vitro ...
Jennifer L, Whitteker, Anil K, Dudani, Eilleen S, Tackaberry   +2 more
openaire   +2 more sources

Superinfection with porcine cytomegalovirus initiating transplacental infection

Veterinary Microbiology, 1988
Four sows with circulating antibody were exposed to porcine cytomegalovirus. Virus was detected in 8 of 24 foetuses by immunofluorescence and/or virus isolation from 2 sows with low levels of antibody. In 6 of the infected foetuses, the virus was in capillary endothelium and macrophages of the lung, and was associated with interlobular oedema in 2 of ...
N, Edington, S, Broad, A E, Wrathall, J T, Done   +3 more
openaire   +2 more sources

Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation.

Transplantation, 2003
A rapidly progressive disorder termed consumptive coagulopathy (CC) has been observed frequently in pig-to-baboon renal xenotransplantation. CC may be initiated by endothelial activation and induction of procoagulant factors after immunologic injury or infection, or by molecular incompatibilities between porcine coagulation proteins and primate ...
Gollackner, Bernd, Mueller, Nicolas J, Houser, Stuart, Qawi, Imrana, Soizic, Daniel, Knosalla, Christoph, Buehler, Leo Hans, Dor, Frank J M F, Awwad, Michel, Sachs, David H, Cooper, David K C, Robson, Simon C, Fishman, Jay A   +12 more
openaire   +3 more sources

Porcine Cytomegalovirus/Porcine Roseolovirus (PCMV/PRV) and Antiviral Drugs

Xenotransplantation
exaly   +3 more sources

A new Western blot assay for the detection of porcine cytomegalovirus (PCMV)

Journal of Immunological Methods, 2016
Porcine cytomegalovirus (PCMV) may be harmful for human recipients if xenotransplantation using pig cell, tissue or organ will be performed transmitting the virus from donor pigs to human recipients. PCMV is widespread in pigs and closely related to human pathogenic herpesviruses, however there are no data concerning infection of humans.
Joachim Denner
exaly   +3 more sources

Porcine Cytomegalovirus (PCMV)

1989
Cytomegalovirus infections are very common in many species (1,2,3,4,5). They induce host specific cytomegalic intranuclear inclusions in various organs. PCMV was first identified as inclusion body rhinitis (IBR) of pigs in Great Britain by Done and coworkers in 1955 (6). Obviously PCMV is inapparently present in most pig herds and causes generally mild
openaire   +1 more source

Electron Microscopy of Porcine Cytomegalovirus in Pig Lung Macrophage Cultures

Zentralblatt für Veterinärmedizin Reihe B, 2010
Summary Two strains of porcine cytomegalovirus (PCMV), strain B 4 and the reference strain ADRI-1, were studied in culture of pig lung macrophages (PLM) by electron microscopy. The nuclei of PLM contained various forms of nucleocapsids of differing core structure.
L, Valícek, B, Smíd
openaire   +2 more sources

HUMAN CYTOMEGALOVIRUS PRODUCTIVELY INFECTS PORCINE ENDOTHELIAL CELLS IN VITRO

Transplantation, 2001
The possibility that human cytomegalovirus (HCMV) may infect porcine endothelial cells (ECs) was investigated. This may be relevant during xenotransplantation of porcine cells or organs into human recipients.HCMV was inoculated into low-passage porcine ECs.
M, Degré, T, Ranneberg-Nilsen, S, Beck, H, Rollag, A E, Fiane   +4 more
openaire   +2 more sources

Identification and Sequence Analysis of the Glycoprotein B Gene of Porcine Cytomegalovirus

Virus Genes, 2001
Porcine cytomegalovirus (PCMV) is one of the pathogens that should be eliminated from pigs intended for use as organ donors in xenotransplantation. For this purpose, reliable diagnostic test systems are needed. To provide a basis for this goal and to analyse the evolutionary relationships of PCMV within the herpesvirus family, the putative glycoprotein
F, Widen, M, Goltz, N, Wittenbrink, B, Ehlers, M, Banks, S, Belak   +5 more
openaire   +2 more sources

Electron microscopy of porcine cytomegalovirus

Archiv für die gesamte Virusforschung, 1973
Porcine cytomegalovirus was examined by electron microscopy in the nasal mucosa of piglets from a natural epizootic of the disease with the object to determine the localization of nucleocapsids arranged in crystalline arrays in the cell and to investigate the structure of most common viral forms. The study revealed the following. 1.
L, Valícek, B, Smíd, J, Mensík
openaire   +2 more sources