Results 71 to 80 of about 148,131 (169)

Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene [PDF]

, 1989
In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the ...
Lubon, H, Hennighausen, L, Nelson, J, Reynolds-Kohler, C, Ghazal, Peter, Lockshin, C, Ghazal, P   +6 more
core   +1 more source

Antibodies Are Not Essential for the Resolution of Primary Cytomegalovirus Infection but Limit Dissemination of Recurrent Virus [PDF]

, 1994
Virus shedding from the epithelial cells of the serous acini of salivary glands is a major source for the horizontal transmission of cytomegalovirus. These cells are, different to other tissues, exempt from CD8 T lymphocyte control. CD4 T lymphocytes are
Crnkovic, Irena, Koszinowski, Ulrich H., Koszinovski, UH, I Crnković, U H Koszinowski, Pavic, Ivica, S Jonjić, Lucin, Pero, I Pavić, B Polić, P Lucin, Polic, Bojan, Jonjic, Stipan   +12 more
core   +2 more sources

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, Volume 13, Issue 49, 3 September 2026.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Specific Knockdown of Gene Expression in the Mature Rat Pineal Gland: The Cone‐Rod Homeodomain Transcription Factor Regulates Melatonin Synthesis In Vivo

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT Melatonin is synthesised from tryptophan by the sequential action of enzymes that are highly expressed in the pineal gland. Homeobox gene‐encoded transcription factors typically control organ development; however, a set of homeobox genes is strongly expressed in the adult pineal gland.
Nicole Anne Morrissey, Tenna Bering, Aurea Susana Blancas‐Velázquez, Jakob Albrethsen, Nicolai J. Wewer Albrechtsen, Martin Fredensborg Rath   +5 more
wiley   +1 more source

Replication of Porcine Cytomegalovirus in the 19-PFT Cell Line.

Journal of Veterinary Medical Science, 1992
Replication of porcine cytomegalovirus was examined in fibroblast- and epithelial-like cell lines of the 19-PFT cell line derived from pig fallopian tube. The virus grew well in the fibroblast-like cell line than the epithelial-like cell line. Cytomegalic cytopathic effects of the virus were clearly observed under the microscope after dispersion of the
KAWAMURA, Hitoshi, TAJIMA, Tomoko, HIRONAO, Takeshi, KAJIKAWA, Taketsugu, KOTANI, Takao   +4 more
openaire   +3 more sources

Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Xenotransplantation represents a potential solution to the persistent global organ shortage, yet its clinical application remains stalled by complex immunologic responses, coagulation dysregulation, species‐specific biology, and infectious risks.
Kasra Shirini, Zoe Hahn, Joseph M. Ladowski, Alexander Schulick, Saghar Babadi, Alexandre Loupy, Kazuhiko Yamada, Raphael P. H. Meier   +7 more
wiley   +1 more source

Identification of the Porcine Cytomegalovirus Major Capsid Protein Gene.

Journal of Veterinary Medical Science, 2001
A major capsid protein (MCP) gene homologue of porcine cytomegalovirus (PCMV) was identified. Sequence analysis indicated that the PCMV MCP gene is 4,026 nucleotides in length encoding a protein of 1,341 amino acid residues. The predicted molecular weight of the PCMV MCP is 151,456 Da, equivalent to those of other herpesvirus MCP counterparts ...
RUPASINGHE, Vasantha, IWATSUKI-HORIMOTO, Kiyoko, SUGII, Shunji, HORIMOTO, Taisuke   +3 more
openaire   +3 more sources

Genetic analysis of M94 of murine cytomegalovirus [PDF]

, 2010
The M94 gene of murine cytomegalovirus (MCMV) is one of the about 40 core genes of the subfamily of β-Herpesvirinae with unknown function. MCMV is utilised as an in vivo model for studying human cytomegalovirus (HCMV) due to the strict species specifity ...
Maninger, Silke
core   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, Volume 13, Issue 45, 13 August 2026.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Progress in Orthotopic Pig Heart Transplantation in Nonhuman Primates

Transplant International
Xenotransplantation of porcine hearts has become a promising alternative to human allotransplantation, where organ demand still greatly surpasses organ availability. Before entering the clinic, however, feasibility of cardiac xenotransplantation needs to
Matthias Längin, Martin Bender, Michael Schmoeckel, Bruno Reichart   +3 more
doaj   +1 more source