Results 81 to 90 of about 13,344 (185)

Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro [PDF]

, 2014
BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) infection leads to substantial economic losses to the swine industry worldwide. However, no effective countermeasures exist to combat this virus infection so far.
Delin Mo, Jintao Gao, Liangliang Wang, Qianqian Ji, Shuqi Xiao, Xiaohong Liu, Xiaoyu Zhang, Yaosheng Chen, Yue Wang   +8 more
core   +1 more source

Is There an Ethical Dilemma in Xenotransplantation?

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring because of the potential risk of zoonotic or xenozoonotic infections affecting third parties.
Joachim Denner
wiley   +1 more source

Xenotransplantation: past, present, and future [PDF]

, 2017
PURPOSE OF REVIEW: To review the progress in the field of xenotransplantation with special attention to most recent encouraging findings which will eventually bring xenotransplantation to the clinic in the near future.
Cooper, David K.C., Ekser, Burcin, Li, Ping   +2 more
core   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Replication of Porcine Cytomegalovirus in the 19-PFT Cell Line.

Journal of Veterinary Medical Science, 1992
Replication of porcine cytomegalovirus was examined in fibroblast- and epithelial-like cell lines of the 19-PFT cell line derived from pig fallopian tube. The virus grew well in the fibroblast-like cell line than the epithelial-like cell line. Cytomegalic cytopathic effects of the virus were clearly observed under the microscope after dispersion of the
H, Kawamura, T, Tajima, T, Hironao, T, Kajikawa, T, Kotani   +4 more
openaire   +3 more sources

Safety of Xenotransplantation: Development of screening methods and testing for porcine viruses [PDF]

, 2018
Xenotransplantation using pig cells, tissues or organs might be a promising solution to overcome the shortage for organs suitable for allotransplantation. Because of several reasons, the pig is currently the favoured donor species.
Janich geb. Plotzki, Elena
core   +1 more source

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

Small, Volume 22, Issue 22, 17 April 2026.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu, Jazmina L. Gonzalez Cruz, Rabina Giri, Yuexiao Zhang, Sahra Bashiri, Leslie C. Domínguez Cadena, Shuhang Li, Zeinab G. Khalil, Waleed M. Hussein, Jingwen Wang, Jolynn Kiong, Xuehan Lu, Jiahui Zhang, Miao Lu, Wenbin Huang, Wei Yang Kong, Ummey Jannatun Nahar, Prashamsa Koirala, Zhong Guo, Patricia Walden, Antje Blumenthal, Jakob Begun, Kirill Alexandrov, Istvan Toth, Rachel J. Stephenson, Mariusz Skwarczynski   +25 more
wiley   +1 more source

Progress in Orthotopic Pig Heart Transplantation in Nonhuman Primates

Transplant International
Xenotransplantation of porcine hearts has become a promising alternative to human allotransplantation, where organ demand still greatly surpasses organ availability. Before entering the clinic, however, feasibility of cardiac xenotransplantation needs to
Matthias Längin, Martin Bender, Michael Schmoeckel, Bruno Reichart   +3 more
doaj   +1 more source

A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen Minipigs

Viruses, 2019
Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger, Yannick Kristiansen, Emelie Reuber, Lars Möller, Michael Laue, Christian Reimer, Joachim Denner   +6 more
doaj   +1 more source

Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. [PDF]

, 2020
Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of
Gao, Li, Ho, Sunita P, Kamarajan, Pachiyappan, Kang, Misun, Kapila, Yvonne L, Kuraji, Ryutaro, Le, Charles, Martinez, April, Rangé, Hélène, Reza Sailani, M, Ye, Changchang, Zhan, Ling, Zhang, Martin Jinye   +12 more
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