Results 11 to 20 of about 33,056 (253)
The pore structure of Clostridium perfringens epsilon toxin
Nature Communications, 2019 Epsilon toxin (Etx) is a potent pore forming toxin (PFT) produced by Clostridium perfringens. Here authors show the cryo-EM structure of the Etx pore assembled on the membrane of susceptible cells and shed light on pore formation and mutant phenotypes.
Christos G. Savva +7 more
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NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens
Toxins, 2010 The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains.
Anthony L. Keyburn +3 more
doaj +3 more sources
Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum. [PDF]
PLoS Pathogens, 2009 Programmed necrosis is a mechanism of cell death that has been described for neuronal excitotoxicity and ischemia/reperfusion injury, but has not been extensively studied in the context of exposure to bacterial exotoxins.
Catherine L Kennedy +4 more
doaj +1 more source
Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin. [PDF]
PLoS ONE, 2015 The plethora of virulence factors associated with Staphylococcus aureus make this bacterium an attractive candidate for a molecularly-designed epitope-focused vaccine.
Jon Oscherwitz, Kemp B Cease
doaj +1 more source
Enhanced SnapShot: Pore-Forming Toxins [PDF]
Cell, 2010 Enhanced SnapShots include features only possible online—animations, embedded captions, and dynamic visuals—all accessible by the click of a mouse. The goal of an Enhanced SnapShot is to provide everything currently available with the print SnapShot plus additional layers of information that are accessible through an easy to navigate interface.The ...
Mueller, Marcus, Ban, Nenad
openaire +2 more sources
Pore-Forming Toxins Trigger the Purge [PDF]
Cell Host & Microbe, 2016 The intestinal epithelium responds to pathogens by coordinating microbial elimination with tissue repair, both required to survive an infection. In this issue of Cell Host & Microbe, Lee et al. (2016) discover a rapid and evolutionarily conserved response to pore-forming toxins in the gut, involving cytoplasm ejection and enterocyte regrowth.
Alessandro, Bonfini, Nicolas, Buchon
openaire +2 more sources
Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins [PDF]
Frontiers in Immunology, 2022 Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis.
Thomas J. R. Ormsby +6 more
openaire +5 more sources
Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
Toxins, 2019 Pore-forming toxins (PFTs) form nanoscale pores across target membranes causing cell death. The pore-forming cytolysins of the RTX (repeats in toxin) family belong to a steadily increasing family of proteins characterized by having in their primary ...
Helena Ostolaza +5 more
doaj +1 more source
Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane
Nature Communications, 2021 The Vip3 family proteins from Bacillus thuringiensis are thought to exert their insecticidal activity through pore formation. Here authors present cryo-EM structures of a Vip3 family toxin in both inactive and activated forms and show the activated ...
Matthew J. Byrne +9 more
doaj +1 more source
Repair of a Bacterial Small β-Barrel Toxin Pore Depends on Channel Width
mBio, 2017 Membrane repair emerges as an innate defense protecting target cells against bacterial pore-forming toxins. Here, we report the first paradigm of Ca2+-dependent repair following attack by a small β-pore-forming toxin, namely, plasmid-encoded phobalysin ...
Gisela von Hoven +7 more
doaj +1 more source