Results 41 to 50 of about 33,056 (253)

Clostridial pore-forming toxins: Powerful virulence factors [PDF]

Anaerobe, 2014
Pore formation is a common mechanism of action for many bacterial toxins. More than one third of clostridial toxins are pore-forming toxins (PFTs) belonging to the β-PFT class. They are secreted as soluble monomers rich in β-strands, which recognize a specific receptor on target cells and assemble in oligomers.
openaire   +3 more sources

A biomimetic nanosponge that absorbs pore-forming toxins [PDF]

Nature Nanotechnology, 2013
Detoxification treatments such as toxin-targeted anti-virulence therapy offer ways to cleanse the body of virulence factors that are caused by bacterial infections, venomous injuries and biological weaponry. Because existing detoxification platforms such as antisera, monoclonal antibodies, small-molecule inhibitors and molecularly imprinted polymers ...
Hu, Che-Ming J., Fang, Ronnie H., Copp, Jonathan, Luk, Brian T., Zhang, Liangfang   +4 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-Toxin

Frontiers in Cellular and Infection Microbiology, 2018
c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiation.
Alejandro J. Moyano, Alejandro J. Moyano, Ana C. Racca, Ana C. Racca, Gastón Soria, Gastón Soria, Héctor A. Saka, Héctor A. Saka, Verónica Andreoli, Verónica Andreoli, Andrea M. Smania, Andrea M. Smania, Claudia Sola, Claudia Sola, José L. Bocco, José L. Bocco   +15 more
doaj   +1 more source

Resurfacing receptor binding domain of Colicin N to enhance its cytotoxic effect on human lung cancer cells

Computational and Structural Biotechnology Journal, 2021
Colicin N (ColN) is a bacteriocin secreted by Escherichia coli (E. coli) to kill other Gram-negative bacteria by forcefully generating ion channels in the inner membrane.
Wanatchaporn Arunmanee, Methawee Duangkaew, Pornchanok Taweecheep, Kanokpol Aphicho, Panuwat Lerdvorasap, Jesada Pitchayakorn, Chayada Intasuk, Runglada Jiraratmetacon, Armini Syamsidi, Pithi Chanvorachote, Chatchai Chaotham, Natapol Pornputtapong   +11 more
doaj   +1 more source

Pore-forming activity of clostridial binary toxins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016
Clostridial binary toxins (Clostridium perfringens Iota toxin, Clostridium difficile transferase, Clostridium spiroforme toxin, Clostridium botulinum C2 toxin) as Bacillus binary toxins, including Bacillus anthracis toxins consist of two independent proteins, one being the binding component which mediates the internalization into cell of the ...
Knapp, O., Benz, R., Popoff, Michel Robert   +2 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cytotoxic Effect of Recombinant Fragaceatoxin C on Peripheral Blood Mononuclear Cells [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objectives: Actinoporins from sea anemones are potent pore-forming toxins. Fragaceatoxin C belongs to this family with a molecular weight of 20 kDa that mainly binds sphingomyelin in membranes and forming 2nm in diameter cation-selective ...
Leyla Darbarfard, Mehdi Imani, Seyyed Meysam Abtahi Froushani   +2 more
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Serine clamp of Clostridium perfringens binary toxin BECb (CPILEb)-pore confers cytotoxicity and enterotoxicity

Communications Biology
BEC (CPILE) is a virulence factor of the pathogen, Clostridium perfringens, which has caused foodborne outbreaks in Japan. BEC is a binary toxin that comprises the enzymatic A-component (BECa) and the B-component (BECb); the latter forms a membrane pore ...
Toru Yoshida, Chie Monma, Yuki Ninomiya, Sotaro Takiguchi, Shoko Fujita, Yuto Uchida, Noriaki Sakoda, Vladimir A. Karginov, Jun-ichi Kishikawa, Tomohito Yamada, Ryuji Kawano, Hideaki Tsuge   +11 more
doaj   +1 more source