Results 181 to 190 of about 25,125 (214)

Trypanosoma cruzi:Resistance to the Pore Forming Protein of Cytotoxic Lymphocytes—Perforin

Experimental Parasitology, 1997
The pore-forming protein perforin is one of the main effector molecules which cytotoxic lymphocytes utilize to kill their targets both in vivo and in vitro. Natural killer cells and cytotoxic T lymphocytes play an important role in host defense against a number of intracellular microorganisms such as virus and protozoan, but the exact way they help ...
R da C, Bisaggio, S L, de Castro, H S, Barbosa, C de A, Brandão, P M, Persechini   +4 more
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Potentiation of anticancer-drug cytotoxicity by sea anemone pore-forming proteins in human glioblastoma cells

Anti-Cancer Drugs, 2008
The search for new drugs and treatment approaches is of particular importance for glioblastomas (GBMs), as with other types of malignant gliomas, as they are lethal without the available medical care. Current anticancer cocktails have failed to prolong survival beyond 1 year, in part owing to the natural resistance of GBM cells and to the toxic side ...
Rossana C, Soletti, Giselle Pinto, de Faria, Javier, Vernal, Hernán, Terenzi, Gregor, Anderluh, Helena L, Borges, Vivaldo, Moura-Neto, Nelson H, Gabilan   +7 more
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Functional characterization of Helicobacter pylori TlyA: Pore-forming hemolytic activity and cytotoxic property of the protein

Biochemical and Biophysical Research Communications, 2014
Helicobacter pylori is a human specific gastric pathogen. H. pylori pathogenesis process involves a number of well-studied virulence factors that include the 'vacuolating cytotoxin' and the 'cytotoxin associated gene A'. Analysis of the H. pylori genome, however, indicates presence of additional virulence factors that are yet to be characterized in ...
Kusum Lata, Karan Paul, Kausik Chattopadhyay   +2 more
openaire   +2 more sources

Molecular mechanisms of cytotoxicity mediated by Entamoeba histolytica: Characterization of a pore‐forming protein (PFP)

Journal of Cellular Biochemistry, 1985
AbstractEntamoeba histolytica is the human pathogen responsible for amebiasis. This infection is characterized by an invasive enteric illness that may spread to multiple organs. The parasite E histolytica may now be cultivated in vitro, with Diamond's axenic medium [1].
J D, Young, Z A, Cohn
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Resistance to the pore-forming protein of cytotoxic T cells: Comparison of target cell membrane rigidity

Molecular Immunology, 1990
Cytotoxic T lymphocytes (CTL) release from their granules a 70 kDa protein, called PFP, perforin or cytolysin, which inserts into the target cell plasma membrane in its monomeric form. Here it polymerizes into a macromolecular complex forming pores as large as 20 nm. Although purified PFP/perforin can effectively lyze all target cells tested.
D M, Ojcius, S B, Jiang, P M, Persechini, J, Storch, J D, Young   +4 more
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IL-7 regulation of cytotoxic lymphocytes: Pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocyte subsets

Cellular Immunology, 1991
The effects of IL-7 on the generation of cytolytic human peripheral blood lymphocytes (PBL) were investigated. Induction of T-cell pore-forming protein (PFP) mRNA and cytotoxic potential by IL-7 was both slow and minor compared with that observed in IL-2-cultured T cells.
M J, Smyth, Y, Norihisa, J R, Gerard, H A, Young, J R, Ortaldo   +4 more
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Pore‐forming protein in individual cytotoxic T lymphocytes: the effect of senescence provides a probe for understanding the lytic mechanism

European Journal of Immunology, 1992
AbstractThe senescent decline of cytolytic T lymphocyte (CTL) activity was examined (a) to learn more about the effect of aging on the immune system, and (b) to probe the mechanism of cell‐mediated cytolysis. The effect of age on the generation of pore‐forming protein (Pfp) was examined at the cellular level in a murine model using CTL stimulated in ...
J A, Horvath, H S, Mostowski, K, Okumura, E T, Bloom   +3 more
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Calcium is essential for both the membrane binding and lytic activity of pore-forming protein (perforin) from cytotoxic T-lymphocyte

Molecular Immunology, 1990
The influence of Ca on the membrane binding and lytic activity of lymphocyte pore-forming protein (perforin) was studied. In the absence of Ca, perforin did not bind to the target membranes and did not support lysis of the target cells. In contrast, in the presence of Ca perforin was able to bind to the cell membrane (Km greater than 0.2 mM).
S, Ishiura, K, Matsuda, H, Koizumi, T, Tsukahara, K, Arahata, H, Sugita   +5 more
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The Ninth Component of Complement and the Pore-Forming Protein (Perforin 1) from Cytotoxic T Cells: Structural, Immunological, and Functional Similarities

Science, 1986
The ninth component of complement (C9) and the pore-forming protein (PFP or perforin) from cytotoxic T lymphocytes polymerize to tubular lesions having an internal diameter of 100 Å and 160 Å, respectively, when bound to lipid bilayers.
J D, Young, Z A, Cohn, E R, Podack
openaire   +2 more sources