Results 21 to 30 of about 25,125 (214)

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

Cell Reports, 2013
Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen interactions.
Steven Johnson, Nicholas J. Brooks, Richard A.G. Smith, Susan M. Lea, Doryen Bubeck   +4 more
doaj   +1 more source

Structural Insights into Clostridium perfringens Delta Toxin Pore Formation.

PLoS ONE, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
Jessica Huyet, Claire E Naylor, Christos G Savva, Maryse Gibert, Michel R Popoff, Ajit K Basak   +5 more
doaj   +1 more source

The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function. [PDF]

PLoS ONE, 2011
Many gram-negative bacteria use type III secretion systems to translocate effector proteins into host cells. These effectors interfere with cellular functions in a highly regulated manner resulting in effects that are beneficial for the bacteria.
Sara E Thorslund, Tomas Edgren, Jonas Pettersson, Roland Nordfelth, Mikael E Sellin, Ekaterina Ivanova, Matthew S Francis, Elin L Isaksson, Hans Wolf-Watz, Maria Fällman   +9 more
doaj   +1 more source

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Frontiers in Immunology, 2018
The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis.
Jamie A. Lopez, Jamie A. Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S. Hildebrand, Hedieh Akhlaghi, Phillip K. Darcy, Phillip K. Darcy, Michael H. Kershaw, Michael H. Kershaw, Natasha J. Brown, Andrew Grigg, Joseph A. Trapani, Joseph A. Trapani, Ilia Voskoboinik, Ilia Voskoboinik   +17 more
doaj   +1 more source

The Bacillus cereus Hbl and Nhe tripartite enterotoxin components assemble sequentially on the surface of target cells and are not interchangeable. [PDF]

PLoS ONE, 2013
Bacillus cereus is a spore-forming, Gram-positive bacterium commonly associated with outbreaks of food poisoning. It is also known as an opportunistic pathogen causing clinical infections such as bacteremia, meningitis, pneumonia, and gas gangrene-like ...
Inka Sastalla, Rasem Fattah, Nicole Coppage, Poulomi Nandy, Devorah Crown, Andrei P Pomerantsev, Stephen H Leppla   +6 more
doaj   +1 more source

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

BMC Evolutionary Biology, 2012
Background The pore-forming protein perforin is central to the granule-exocytosis pathway used by cytotoxic lymphocytes to kill abnormal cells. Although this mechanism of killing is conserved in bony vertebrates, cytotoxic cells are present in other ...
D’Angelo Michael E, Dunstone Michelle A, Whisstock James C, Trapani Joseph A, Bird Phillip I   +4 more
doaj   +1 more source

Identification of a pore-forming protein from sea anemone Anthopleura dowii Verrill (1869) venom by mass spectrometry

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Pore-forming proteins (PFP) are a class of toxins abundant in the venom of sea anemones. Owing to their ability to recognize and permeabilize cell membranes, pore-forming proteins have medical potential in cancer therapy or as ...
Santos Ramírez-Carreto, Erick I. Pérez-García, Sandra I. Salazar-García, Johanna Bernáldez-Sarabia, Alexei Licea-Navarro, Enrique Rudiño-Piñera, Leonor Pérez-Martínez, Gustavo Pedraza-Alva, Claudia Rodríguez-Almazán   +8 more
doaj   +1 more source

A novel pore-forming toxin in type A Clostridium perfringens is associated with both fatal canine hemorrhagic gastroenteritis and fatal foal necrotizing enterocolitis.

PLoS ONE, 2015
A role for type A Clostridium perfringens in acute hemorrhagic and necrotizing gastroenteritis in dogs and in necrotizing enterocolitis of neonatal foals has long been suspected but incompletely characterized.
Iman Mehdizadeh Gohari, Valeria R Parreira, Victoria J Nowell, Vivian M Nicholson, Kaitlyn Oliphant, John F Prescott   +5 more
doaj   +1 more source

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

Journal of Neuroinflammation, 2020
Background Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein.
Brienne A. McKenzie, Jason P. Fernandes, Matthew A. L. Doan, Laura M. Schmitt, William G. Branton, Christopher Power   +5 more
doaj   +1 more source

Pseudomonas aeruginosa Pore-Forming Exolysin and Type IV Pili Cooperate To Induce Host Cell Lysis

mBio, 2017
Clinical strains of Pseudomonas aeruginosa lacking the type III secretion system genes employ a toxin, exolysin (ExlA), for host cell membrane disruption.
Pauline Basso, Michel Ragno, Sylvie Elsen, Emeline Reboud, Guillaume Golovkine, Stephanie Bouillot, Philippe Huber, Stephen Lory, Eric Faudry, Ina Attrée   +9 more
doaj   +1 more source